Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R
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Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. / Freitag, Sandra; Schachner, Melitta; Morellini, Fabio.
In: BEHAV BRAIN RES, Vol. 145, No. 1-2, 17.10.2003, p. 189-207.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R
AU - Freitag, Sandra
AU - Schachner, Melitta
AU - Morellini, Fabio
PY - 2003/10/17
Y1 - 2003/10/17
N2 - We investigated the behavior of mice deficient for the extracellular matrix (ECM) glycoprotein tenascin-R (TN-R) in comparison to their wild-type (WT) littermates. A longitudinal study including tests for exploration and anxiety, motor coordination and cognition was carried out. Mice were tested at different ages, ranging from 3 weeks to 11 months and under different housing conditions. TN-R deficient mice displayed decreased motivation to explore and an increased anxiety profile in the free choice open field (FCOF), open field (OF) and elevated plus maze (EPM) tests. Moreover, the anxiety level of TN-R deficient mice was more strongly influenced by environmental factors as compared to WT littermates. TN-R deficient mice showed motor coordination impairments in the wire hanging, Rotarod and pole test. Thus TN-R ablation leads to an altered behavioral phenotype in mice that may negatively affect their fitness under natural conditions.
AB - We investigated the behavior of mice deficient for the extracellular matrix (ECM) glycoprotein tenascin-R (TN-R) in comparison to their wild-type (WT) littermates. A longitudinal study including tests for exploration and anxiety, motor coordination and cognition was carried out. Mice were tested at different ages, ranging from 3 weeks to 11 months and under different housing conditions. TN-R deficient mice displayed decreased motivation to explore and an increased anxiety profile in the free choice open field (FCOF), open field (OF) and elevated plus maze (EPM) tests. Moreover, the anxiety level of TN-R deficient mice was more strongly influenced by environmental factors as compared to WT littermates. TN-R deficient mice showed motor coordination impairments in the wire hanging, Rotarod and pole test. Thus TN-R ablation leads to an altered behavioral phenotype in mice that may negatively affect their fitness under natural conditions.
KW - Aggression
KW - Aging
KW - Analysis of Variance
KW - Animals
KW - Anxiety
KW - Behavior, Animal
KW - Body Weight
KW - Choice Behavior
KW - Cognition
KW - Cues
KW - Environment
KW - Exploratory Behavior
KW - Longitudinal Studies
KW - Maze Learning
KW - Mice
KW - Mice, Knockout
KW - Motor Activity
KW - Movement
KW - Psychomotor Performance
KW - Tenascin
KW - Time Factors
M3 - SCORING: Journal article
C2 - 14529817
VL - 145
SP - 189
EP - 207
JO - BEHAV BRAIN RES
JF - BEHAV BRAIN RES
SN - 0166-4328
IS - 1-2
ER -