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Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R

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Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. / Freitag, Sandra; Schachner, Melitta; Morellini, Fabio.

in: BEHAV BRAIN RES, Jahrgang 145, Nr. 1-2, 17.10.2003, S. 189-207.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Freitag, S, Schachner, M & Morellini, F 2003, 'Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R', BEHAV BRAIN RES, Jg. 145, Nr. 1-2, S. 189-207.

APA

Freitag, S., Schachner, M., & Morellini, F. (2003). Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. BEHAV BRAIN RES, 145(1-2), 189-207.

Vancouver

Freitag S, Schachner M, Morellini F. Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. BEHAV BRAIN RES. 2003 Okt 17;145(1-2):189-207.

Bibtex

@article{ccdb2dd2622f40128396bf99d525884b,
title = "Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R",
abstract = "We investigated the behavior of mice deficient for the extracellular matrix (ECM) glycoprotein tenascin-R (TN-R) in comparison to their wild-type (WT) littermates. A longitudinal study including tests for exploration and anxiety, motor coordination and cognition was carried out. Mice were tested at different ages, ranging from 3 weeks to 11 months and under different housing conditions. TN-R deficient mice displayed decreased motivation to explore and an increased anxiety profile in the free choice open field (FCOF), open field (OF) and elevated plus maze (EPM) tests. Moreover, the anxiety level of TN-R deficient mice was more strongly influenced by environmental factors as compared to WT littermates. TN-R deficient mice showed motor coordination impairments in the wire hanging, Rotarod and pole test. Thus TN-R ablation leads to an altered behavioral phenotype in mice that may negatively affect their fitness under natural conditions.",
keywords = "Aggression, Aging, Analysis of Variance, Animals, Anxiety, Behavior, Animal, Body Weight, Choice Behavior, Cognition, Cues, Environment, Exploratory Behavior, Longitudinal Studies, Maze Learning, Mice, Mice, Knockout, Motor Activity, Movement, Psychomotor Performance, Tenascin, Time Factors",
author = "Sandra Freitag and Melitta Schachner and Fabio Morellini",
year = "2003",
month = oct,
day = "17",
language = "English",
volume = "145",
pages = "189--207",
journal = "BEHAV BRAIN RES",
issn = "0166-4328",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R

AU - Freitag, Sandra

AU - Schachner, Melitta

AU - Morellini, Fabio

PY - 2003/10/17

Y1 - 2003/10/17

N2 - We investigated the behavior of mice deficient for the extracellular matrix (ECM) glycoprotein tenascin-R (TN-R) in comparison to their wild-type (WT) littermates. A longitudinal study including tests for exploration and anxiety, motor coordination and cognition was carried out. Mice were tested at different ages, ranging from 3 weeks to 11 months and under different housing conditions. TN-R deficient mice displayed decreased motivation to explore and an increased anxiety profile in the free choice open field (FCOF), open field (OF) and elevated plus maze (EPM) tests. Moreover, the anxiety level of TN-R deficient mice was more strongly influenced by environmental factors as compared to WT littermates. TN-R deficient mice showed motor coordination impairments in the wire hanging, Rotarod and pole test. Thus TN-R ablation leads to an altered behavioral phenotype in mice that may negatively affect their fitness under natural conditions.

AB - We investigated the behavior of mice deficient for the extracellular matrix (ECM) glycoprotein tenascin-R (TN-R) in comparison to their wild-type (WT) littermates. A longitudinal study including tests for exploration and anxiety, motor coordination and cognition was carried out. Mice were tested at different ages, ranging from 3 weeks to 11 months and under different housing conditions. TN-R deficient mice displayed decreased motivation to explore and an increased anxiety profile in the free choice open field (FCOF), open field (OF) and elevated plus maze (EPM) tests. Moreover, the anxiety level of TN-R deficient mice was more strongly influenced by environmental factors as compared to WT littermates. TN-R deficient mice showed motor coordination impairments in the wire hanging, Rotarod and pole test. Thus TN-R ablation leads to an altered behavioral phenotype in mice that may negatively affect their fitness under natural conditions.

KW - Aggression

KW - Aging

KW - Analysis of Variance

KW - Animals

KW - Anxiety

KW - Behavior, Animal

KW - Body Weight

KW - Choice Behavior

KW - Cognition

KW - Cues

KW - Environment

KW - Exploratory Behavior

KW - Longitudinal Studies

KW - Maze Learning

KW - Mice

KW - Mice, Knockout

KW - Motor Activity

KW - Movement

KW - Psychomotor Performance

KW - Tenascin

KW - Time Factors

M3 - SCORING: Journal article

C2 - 14529817

VL - 145

SP - 189

EP - 207

JO - BEHAV BRAIN RES

JF - BEHAV BRAIN RES

SN - 0166-4328

IS - 1-2

ER -