Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage

TY - JOUR

T1 - Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage

AU - Anetsberger, Aida

AU - Jungwirth, Bettina

AU - Blobner, Manfred

AU - Ringel, Florian

AU - Bernlochner, Isabell

AU - Heim, Markus

AU - Bogdanski, Ralph

AU - Wostrack, Maria

AU - Schneider, Gerhard

AU - Meyer, Bernhard

AU - Graeßner, Martin

AU - Baumgart, Lea

AU - Gempt, Jens

N1 - © 2021. The Author(s).

PY - 2021/8/9

Y1 - 2021/8/9

N2 - TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1-3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.

AB - TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1-3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.

KW - Aged

KW - Biomarkers/blood

KW - Female

KW - Glasgow Outcome Scale

KW - Hemodynamics

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Subarachnoid Hemorrhage/blood

KW - Time Factors

KW - Treatment Outcome

KW - Troponin T/blood

U2 - 10.1038/s41598-021-95717-w

DO - 10.1038/s41598-021-95717-w

M3 - SCORING: Journal article

C2 - 34373566

VL - 11

SP - 16154

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -