Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage
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Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage. / Anetsberger, Aida; Jungwirth, Bettina; Blobner, Manfred; Ringel, Florian; Bernlochner, Isabell; Heim, Markus; Bogdanski, Ralph; Wostrack, Maria; Schneider, Gerhard; Meyer, Bernhard; Graeßner, Martin; Baumgart, Lea; Gempt, Jens.
in: SCI REP-UK, Jahrgang 11, Nr. 1, 09.08.2021, S. 16154.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage
AU - Anetsberger, Aida
AU - Jungwirth, Bettina
AU - Blobner, Manfred
AU - Ringel, Florian
AU - Bernlochner, Isabell
AU - Heim, Markus
AU - Bogdanski, Ralph
AU - Wostrack, Maria
AU - Schneider, Gerhard
AU - Meyer, Bernhard
AU - Graeßner, Martin
AU - Baumgart, Lea
AU - Gempt, Jens
N1 - © 2021. The Author(s).
PY - 2021/8/9
Y1 - 2021/8/9
N2 - TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1-3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.
AB - TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1-3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.
KW - Aged
KW - Biomarkers/blood
KW - Female
KW - Glasgow Outcome Scale
KW - Hemodynamics
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Prospective Studies
KW - Subarachnoid Hemorrhage/blood
KW - Time Factors
KW - Treatment Outcome
KW - Troponin T/blood
U2 - 10.1038/s41598-021-95717-w
DO - 10.1038/s41598-021-95717-w
M3 - SCORING: Journal article
C2 - 34373566
VL - 11
SP - 16154
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -