Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.

Standard

Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort. / Maas, Renke; Xanthakis, Vanessa; Polak, Joseph F; Schwedhelm, Edzard; Sullivan Lisa, M; Benndorf, Ralf; Schulze, Friedrich; Vasan, Ramachandran S; Wolf, Philip A; Böger, Rainer; Seshadri, Sudha.

In: STROKE, Vol. 40, No. 8, 8, 2009, p. 2715-2719.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

APA

Vancouver

Bibtex

@article{d795049544524fb184c1a72c971fb267,
title = "Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.",
abstract = "BACKGROUND AND PURPOSE: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS: In unadjusted analyses, ADMA was positively related to both CCA-IMT (beta per SD increment, 0.012; P",
author = "Renke Maas and Vanessa Xanthakis and Polak, {Joseph F} and Edzard Schwedhelm and {Sullivan Lisa}, M and Ralf Benndorf and Friedrich Schulze and Vasan, {Ramachandran S} and Wolf, {Philip A} and Rainer B{\"o}ger and Sudha Seshadri",
year = "2009",
language = "Deutsch",
volume = "40",
pages = "2715--2719",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.

AU - Maas, Renke

AU - Xanthakis, Vanessa

AU - Polak, Joseph F

AU - Schwedhelm, Edzard

AU - Sullivan Lisa, M

AU - Benndorf, Ralf

AU - Schulze, Friedrich

AU - Vasan, Ramachandran S

AU - Wolf, Philip A

AU - Böger, Rainer

AU - Seshadri, Sudha

PY - 2009

Y1 - 2009

N2 - BACKGROUND AND PURPOSE: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS: In unadjusted analyses, ADMA was positively related to both CCA-IMT (beta per SD increment, 0.012; P

AB - BACKGROUND AND PURPOSE: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS: In unadjusted analyses, ADMA was positively related to both CCA-IMT (beta per SD increment, 0.012; P

M3 - SCORING: Zeitschriftenaufsatz

VL - 40

SP - 2715

EP - 2719

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 8

M1 - 8

ER -