Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.
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Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort. / Maas, Renke; Xanthakis, Vanessa; Polak, Joseph F; Schwedhelm, Edzard; Sullivan Lisa, M; Benndorf, Ralf; Schulze, Friedrich; Vasan, Ramachandran S; Wolf, Philip A; Böger, Rainer; Seshadri, Sudha.
in: STROKE, Jahrgang 40, Nr. 8, 8, 2009, S. 2715-2719.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.
AU - Maas, Renke
AU - Xanthakis, Vanessa
AU - Polak, Joseph F
AU - Schwedhelm, Edzard
AU - Sullivan Lisa, M
AU - Benndorf, Ralf
AU - Schulze, Friedrich
AU - Vasan, Ramachandran S
AU - Wolf, Philip A
AU - Böger, Rainer
AU - Seshadri, Sudha
PY - 2009
Y1 - 2009
N2 - BACKGROUND AND PURPOSE: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS: In unadjusted analyses, ADMA was positively related to both CCA-IMT (beta per SD increment, 0.012; P
AB - BACKGROUND AND PURPOSE: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS: In unadjusted analyses, ADMA was positively related to both CCA-IMT (beta per SD increment, 0.012; P
M3 - SCORING: Zeitschriftenaufsatz
VL - 40
SP - 2715
EP - 2719
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 8
M1 - 8
ER -