Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study
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Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study. / Kallel, Choumous; Cohen, William; Saut, Noémie; Blankenberg, Stefan; Schnabel, Renate; Rupprecht, Hans J; Bickel, Christoph; Munzel, Thomas; Tregouet, David-Alexandre; Morange, Pierre-Emmanuel.
In: BMC MED GENET, Vol. 13, 08.11.2012, p. 103.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study
AU - Kallel, Choumous
AU - Cohen, William
AU - Saut, Noémie
AU - Blankenberg, Stefan
AU - Schnabel, Renate
AU - Rupprecht, Hans J
AU - Bickel, Christoph
AU - Munzel, Thomas
AU - Tregouet, David-Alexandre
AU - Morange, Pierre-Emmanuel
PY - 2012/11/8
Y1 - 2012/11/8
N2 - BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE).METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant.RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk.CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.
AB - BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE).METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant.RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk.CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.
KW - Acute Coronary Syndrome/blood
KW - Angina Pectoris/blood
KW - Antigens, CD/blood
KW - Biomarkers/blood
KW - Cardiovascular Diseases/blood
KW - Coronary Artery Disease/blood
KW - Endothelial Protein C Receptor
KW - Female
KW - Humans
KW - Male
KW - Polymorphism, Single Nucleotide
KW - Receptors, Cell Surface/blood
KW - Risk Factors
U2 - 10.1186/1471-2350-13-103
DO - 10.1186/1471-2350-13-103
M3 - SCORING: Journal article
C2 - 23136988
VL - 13
SP - 103
JO - BMC MED GENET
JF - BMC MED GENET
SN - 1471-2350
ER -