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Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study

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Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study. / Kallel, Choumous; Cohen, William; Saut, Noémie; Blankenberg, Stefan; Schnabel, Renate; Rupprecht, Hans J; Bickel, Christoph; Munzel, Thomas; Tregouet, David-Alexandre; Morange, Pierre-Emmanuel.

in: BMC MED GENET, Jahrgang 13, 08.11.2012, S. 103.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kallel, C, Cohen, W, Saut, N, Blankenberg, S, Schnabel, R, Rupprecht, HJ, Bickel, C, Munzel, T, Tregouet, D-A & Morange, P-E 2012, 'Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study', BMC MED GENET, Jg. 13, S. 103. https://doi.org/10.1186/1471-2350-13-103

APA

Kallel, C., Cohen, W., Saut, N., Blankenberg, S., Schnabel, R., Rupprecht, H. J., Bickel, C., Munzel, T., Tregouet, D-A., & Morange, P-E. (2012). Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study. BMC MED GENET, 13, 103. https://doi.org/10.1186/1471-2350-13-103

Vancouver

Kallel C, Cohen W, Saut N, Blankenberg S, Schnabel R, Rupprecht HJ et al. Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study. BMC MED GENET. 2012 Nov 8;13:103. https://doi.org/10.1186/1471-2350-13-103

Bibtex

@article{b3fa009a5cd94b789ae7e2662567c982,
title = "Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study",
abstract = "BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE).METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant.RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk.CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.",
keywords = "Acute Coronary Syndrome/blood, Angina Pectoris/blood, Antigens, CD/blood, Biomarkers/blood, Cardiovascular Diseases/blood, Coronary Artery Disease/blood, Endothelial Protein C Receptor, Female, Humans, Male, Polymorphism, Single Nucleotide, Receptors, Cell Surface/blood, Risk Factors",
author = "Choumous Kallel and William Cohen and No{\'e}mie Saut and Stefan Blankenberg and Renate Schnabel and Rupprecht, {Hans J} and Christoph Bickel and Thomas Munzel and David-Alexandre Tregouet and Pierre-Emmanuel Morange",
year = "2012",
month = nov,
day = "8",
doi = "10.1186/1471-2350-13-103",
language = "English",
volume = "13",
pages = "103",
journal = "BMC MED GENET",
issn = "1471-2350",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study

AU - Kallel, Choumous

AU - Cohen, William

AU - Saut, Noémie

AU - Blankenberg, Stefan

AU - Schnabel, Renate

AU - Rupprecht, Hans J

AU - Bickel, Christoph

AU - Munzel, Thomas

AU - Tregouet, David-Alexandre

AU - Morange, Pierre-Emmanuel

PY - 2012/11/8

Y1 - 2012/11/8

N2 - BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE).METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant.RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk.CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.

AB - BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE).METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant.RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk.CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.

KW - Acute Coronary Syndrome/blood

KW - Angina Pectoris/blood

KW - Antigens, CD/blood

KW - Biomarkers/blood

KW - Cardiovascular Diseases/blood

KW - Coronary Artery Disease/blood

KW - Endothelial Protein C Receptor

KW - Female

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Receptors, Cell Surface/blood

KW - Risk Factors

U2 - 10.1186/1471-2350-13-103

DO - 10.1186/1471-2350-13-103

M3 - SCORING: Journal article

C2 - 23136988

VL - 13

SP - 103

JO - BMC MED GENET

JF - BMC MED GENET

SN - 1471-2350

ER -