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Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease

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Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. / Sinning, Christoph R; Sinning, Jan-Malte; Schulz, Andreas; Schnabel, Renate B; Lubos, Edith; Wild, Philipp S; Papassotiriou, Jana; Bergmann, Andreas; Blankenberg, Stefan; Munzel, Thomas; Bickel, Christoph; AtheroGene Investigators.

In: CIRC J, Vol. 75, No. 5, 2011, p. 1184-1191.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sinning, CR, Sinning, J-M, Schulz, A, Schnabel, RB, Lubos, E, Wild, PS, Papassotiriou, J, Bergmann, A, Blankenberg, S, Munzel, T, Bickel, C & AtheroGene Investigators 2011, 'Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease', CIRC J, vol. 75, no. 5, pp. 1184-1191. https://doi.org/10.1253/circj.cj-10-0638

APA

Sinning, C. R., Sinning, J-M., Schulz, A., Schnabel, R. B., Lubos, E., Wild, P. S., Papassotiriou, J., Bergmann, A., Blankenberg, S., Munzel, T., Bickel, C., & AtheroGene Investigators (2011). Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. CIRC J, 75(5), 1184-1191. https://doi.org/10.1253/circj.cj-10-0638

Vancouver

Sinning CR, Sinning J-M, Schulz A, Schnabel RB, Lubos E, Wild PS et al. Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. CIRC J. 2011;75(5):1184-1191. https://doi.org/10.1253/circj.cj-10-0638

Bibtex

@article{f297e6bbb17042689a4cc7d5c5131788,
title = "Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease",
abstract = "BACKGROUND: Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD).METHODS AND RESULTS: A total of 2,131 patients with CAD were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 patients and non-fatal myocardial infarction in 85 patients. Median and quartile 1 and 3 are reported for PCT concentration. Patients who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. Patients with acute coronary syndrome had increased concentrations of PCT in relation to patients with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to cardiovascular events (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for C-reactive protein (CRP), PCT did not provide additional prognostic information.CONCLUSIONS: PCT is associated with future cardiovascular mortality in patients with CAD, but PCT is not superior to CRP for prediction of outcome.",
keywords = "Aged, Atherosclerosis/diagnosis, Biomarkers/blood, C-Reactive Protein/analysis, Calcitonin/blood, Calcitonin Gene-Related Peptide, Cardiovascular Diseases/diagnosis, Coronary Artery Disease/diagnosis, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Protein Precursors/blood, Survival Rate",
author = "Sinning, {Christoph R} and Jan-Malte Sinning and Andreas Schulz and Schnabel, {Renate B} and Edith Lubos and Wild, {Philipp S} and Jana Papassotiriou and Andreas Bergmann and Stefan Blankenberg and Thomas Munzel and Christoph Bickel and {AtheroGene Investigators}",
year = "2011",
doi = "10.1253/circj.cj-10-0638",
language = "English",
volume = "75",
pages = "1184--1191",
journal = "CIRC J",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "5",

}

RIS

TY - JOUR

T1 - Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease

AU - Sinning, Christoph R

AU - Sinning, Jan-Malte

AU - Schulz, Andreas

AU - Schnabel, Renate B

AU - Lubos, Edith

AU - Wild, Philipp S

AU - Papassotiriou, Jana

AU - Bergmann, Andreas

AU - Blankenberg, Stefan

AU - Munzel, Thomas

AU - Bickel, Christoph

AU - AtheroGene Investigators

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD).METHODS AND RESULTS: A total of 2,131 patients with CAD were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 patients and non-fatal myocardial infarction in 85 patients. Median and quartile 1 and 3 are reported for PCT concentration. Patients who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. Patients with acute coronary syndrome had increased concentrations of PCT in relation to patients with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to cardiovascular events (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for C-reactive protein (CRP), PCT did not provide additional prognostic information.CONCLUSIONS: PCT is associated with future cardiovascular mortality in patients with CAD, but PCT is not superior to CRP for prediction of outcome.

AB - BACKGROUND: Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD).METHODS AND RESULTS: A total of 2,131 patients with CAD were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 patients and non-fatal myocardial infarction in 85 patients. Median and quartile 1 and 3 are reported for PCT concentration. Patients who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. Patients with acute coronary syndrome had increased concentrations of PCT in relation to patients with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to cardiovascular events (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for C-reactive protein (CRP), PCT did not provide additional prognostic information.CONCLUSIONS: PCT is associated with future cardiovascular mortality in patients with CAD, but PCT is not superior to CRP for prediction of outcome.

KW - Aged

KW - Atherosclerosis/diagnosis

KW - Biomarkers/blood

KW - C-Reactive Protein/analysis

KW - Calcitonin/blood

KW - Calcitonin Gene-Related Peptide

KW - Cardiovascular Diseases/diagnosis

KW - Coronary Artery Disease/diagnosis

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Protein Precursors/blood

KW - Survival Rate

U2 - 10.1253/circj.cj-10-0638

DO - 10.1253/circj.cj-10-0638

M3 - SCORING: Journal article

C2 - 21378450

VL - 75

SP - 1184

EP - 1191

JO - CIRC J

JF - CIRC J

SN - 1346-9843

IS - 5

ER -