Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease
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Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. / Sinning, Christoph R; Sinning, Jan-Malte; Schulz, Andreas; Schnabel, Renate B; Lubos, Edith; Wild, Philipp S; Papassotiriou, Jana; Bergmann, Andreas; Blankenberg, Stefan; Munzel, Thomas; Bickel, Christoph; AtheroGene Investigators.
in: CIRC J, Jahrgang 75, Nr. 5, 2011, S. 1184-1191.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease
AU - Sinning, Christoph R
AU - Sinning, Jan-Malte
AU - Schulz, Andreas
AU - Schnabel, Renate B
AU - Lubos, Edith
AU - Wild, Philipp S
AU - Papassotiriou, Jana
AU - Bergmann, Andreas
AU - Blankenberg, Stefan
AU - Munzel, Thomas
AU - Bickel, Christoph
AU - AtheroGene Investigators
PY - 2011
Y1 - 2011
N2 - BACKGROUND: Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD).METHODS AND RESULTS: A total of 2,131 patients with CAD were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 patients and non-fatal myocardial infarction in 85 patients. Median and quartile 1 and 3 are reported for PCT concentration. Patients who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. Patients with acute coronary syndrome had increased concentrations of PCT in relation to patients with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to cardiovascular events (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for C-reactive protein (CRP), PCT did not provide additional prognostic information.CONCLUSIONS: PCT is associated with future cardiovascular mortality in patients with CAD, but PCT is not superior to CRP for prediction of outcome.
AB - BACKGROUND: Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD).METHODS AND RESULTS: A total of 2,131 patients with CAD were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 patients and non-fatal myocardial infarction in 85 patients. Median and quartile 1 and 3 are reported for PCT concentration. Patients who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. Patients with acute coronary syndrome had increased concentrations of PCT in relation to patients with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to cardiovascular events (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for C-reactive protein (CRP), PCT did not provide additional prognostic information.CONCLUSIONS: PCT is associated with future cardiovascular mortality in patients with CAD, but PCT is not superior to CRP for prediction of outcome.
KW - Aged
KW - Atherosclerosis/diagnosis
KW - Biomarkers/blood
KW - C-Reactive Protein/analysis
KW - Calcitonin/blood
KW - Calcitonin Gene-Related Peptide
KW - Cardiovascular Diseases/diagnosis
KW - Coronary Artery Disease/diagnosis
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Protein Precursors/blood
KW - Survival Rate
U2 - 10.1253/circj.cj-10-0638
DO - 10.1253/circj.cj-10-0638
M3 - SCORING: Journal article
C2 - 21378450
VL - 75
SP - 1184
EP - 1191
JO - CIRC J
JF - CIRC J
SN - 1346-9843
IS - 5
ER -