Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors
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Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors : a PET/CT study. / Janssen, Tido; Bannas, Peter; Herrmann, Jochen; Veldhoen, Simon; Busch, Jasmin D; Treszl, András; Münster, Silvia; Mester, Janos; Derlin, Thorsten.
In: J NUCL CARDIOL, Vol. 20, No. 4, 01.08.2013, p. 569-77.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors
T2 - a PET/CT study
AU - Janssen, Tido
AU - Bannas, Peter
AU - Herrmann, Jochen
AU - Veldhoen, Simon
AU - Busch, Jasmin D
AU - Treszl, András
AU - Münster, Silvia
AU - Mester, Janos
AU - Derlin, Thorsten
PY - 2013/8/1
Y1 - 2013/8/1
N2 - BACKGROUND: The aim of this study was to correlate linear (18)F-sodium fluoride accumulation in the femoral arteries as a measure of diffuse mineral deposition in medial elastocalcinosis with cardiovascular risk factors (RFs) and calcified plaque burden (CPB).METHODS AND RESULTS: In this study, 409 patients were examined by (18)F-sodium fluoride positron emission tomography/computed tomography (PET/CT). Tracer accumulation was analyzed both qualitatively and semiquantitatively by measuring the target-to-background ratio, and compared with cardiovascular RFs and CPB. Linear (18)F-sodium fluoride accumulation was observed in 159 (38.9%) patients and correlated significantly with age (P < .0001), hypertension (P < .0001), hypercholesterolemia (P = .0003), diabetes (P = .0003), history of smoking (P = .0007), prior cardiovascular events (P = .03), and CPB (P < .0001). The prevalence of linear tracer uptake increased as the number of cardiovascular RFs increased (P < .0001).CONCLUSIONS: Linear (18)F-sodium fluoride uptake in the femoral arteries (1) provides a measure of diffuse mineral deposition, (2) demonstrates a highly significant correlation with cardiovascular RFs and CPB, and (3) is found to accumulate more frequently in patients with a high-risk profile for cardiovascular events. (18)F-sodium fluoride PET/CT may become a unique tool for in vivo visualization and quantification of ongoing calcification in large arteries.
AB - BACKGROUND: The aim of this study was to correlate linear (18)F-sodium fluoride accumulation in the femoral arteries as a measure of diffuse mineral deposition in medial elastocalcinosis with cardiovascular risk factors (RFs) and calcified plaque burden (CPB).METHODS AND RESULTS: In this study, 409 patients were examined by (18)F-sodium fluoride positron emission tomography/computed tomography (PET/CT). Tracer accumulation was analyzed both qualitatively and semiquantitatively by measuring the target-to-background ratio, and compared with cardiovascular RFs and CPB. Linear (18)F-sodium fluoride accumulation was observed in 159 (38.9%) patients and correlated significantly with age (P < .0001), hypertension (P < .0001), hypercholesterolemia (P = .0003), diabetes (P = .0003), history of smoking (P = .0007), prior cardiovascular events (P = .03), and CPB (P < .0001). The prevalence of linear tracer uptake increased as the number of cardiovascular RFs increased (P < .0001).CONCLUSIONS: Linear (18)F-sodium fluoride uptake in the femoral arteries (1) provides a measure of diffuse mineral deposition, (2) demonstrates a highly significant correlation with cardiovascular RFs and CPB, and (3) is found to accumulate more frequently in patients with a high-risk profile for cardiovascular events. (18)F-sodium fluoride PET/CT may become a unique tool for in vivo visualization and quantification of ongoing calcification in large arteries.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Calcinosis
KW - Cardiovascular Diseases
KW - Diabetes Complications
KW - Female
KW - Femoral Artery
KW - Fluorine Radioisotopes
KW - Humans
KW - Hypercholesterolemia
KW - Hypertension
KW - Male
KW - Middle Aged
KW - Multimodal Imaging
KW - Neoplasms
KW - Positron-Emission Tomography
KW - Prevalence
KW - Reproducibility of Results
KW - Risk Factors
KW - Smoking
KW - Sodium Fluoride
KW - Tomography, X-Ray Computed
KW - Young Adult
U2 - 10.1007/s12350-013-9680-8
DO - 10.1007/s12350-013-9680-8
M3 - SCORING: Journal article
C2 - 23588862
VL - 20
SP - 569
EP - 577
JO - J NUCL CARDIOL
JF - J NUCL CARDIOL
SN - 1071-3581
IS - 4
ER -