Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study

Tido Janssen; Peter Bannas; Jochen Herrmann; Simon Veldhoen; Jasmin D Busch; András Treszl; Silvia Münster; Janos Mester; Thorsten Derlin

doi:10.1007/s12350-013-9680-8

Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors

Standard

Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors : a PET/CT study. / Janssen, Tido; Bannas, Peter ; Herrmann, Jochen; Veldhoen, Simon; Busch, Jasmin D; Treszl, András; Münster, Silvia; Mester, Janos; Derlin, Thorsten.

in: J NUCL CARDIOL, Jahrgang 20, Nr. 4, 01.08.2013, S. 569-77.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Janssen, T, Bannas, P , Herrmann, J, Veldhoen, S, Busch, JD, Treszl, A, Münster, S, Mester, J & Derlin, T 2013, 'Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study', J NUCL CARDIOL, Jg. 20, Nr. 4, S. 569-77. https://doi.org/10.1007/s12350-013-9680-8

APA

Janssen, T., Bannas, P., Herrmann, J., Veldhoen, S., Busch, J. D., Treszl, A., Münster, S., Mester, J., & Derlin, T. (2013). Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study. J NUCL CARDIOL, 20(4), 569-77. https://doi.org/10.1007/s12350-013-9680-8

Vancouver

Janssen T, Bannas P , Herrmann J, Veldhoen S, Busch JD, Treszl A et al. Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study. J NUCL CARDIOL. 2013 Aug 1;20(4):569-77. https://doi.org/10.1007/s12350-013-9680-8

Bibtex

@article{b222c6367b674d30966f3888f16e0fc8,

title = "Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study",

abstract = "BACKGROUND: The aim of this study was to correlate linear (18)F-sodium fluoride accumulation in the femoral arteries as a measure of diffuse mineral deposition in medial elastocalcinosis with cardiovascular risk factors (RFs) and calcified plaque burden (CPB).METHODS AND RESULTS: In this study, 409 patients were examined by (18)F-sodium fluoride positron emission tomography/computed tomography (PET/CT). Tracer accumulation was analyzed both qualitatively and semiquantitatively by measuring the target-to-background ratio, and compared with cardiovascular RFs and CPB. Linear (18)F-sodium fluoride accumulation was observed in 159 (38.9%) patients and correlated significantly with age (P < .0001), hypertension (P < .0001), hypercholesterolemia (P = .0003), diabetes (P = .0003), history of smoking (P = .0007), prior cardiovascular events (P = .03), and CPB (P < .0001). The prevalence of linear tracer uptake increased as the number of cardiovascular RFs increased (P < .0001).CONCLUSIONS: Linear (18)F-sodium fluoride uptake in the femoral arteries (1) provides a measure of diffuse mineral deposition, (2) demonstrates a highly significant correlation with cardiovascular RFs and CPB, and (3) is found to accumulate more frequently in patients with a high-risk profile for cardiovascular events. (18)F-sodium fluoride PET/CT may become a unique tool for in vivo visualization and quantification of ongoing calcification in large arteries.",

keywords = "Adult, Aged, Aged, 80 and over, Calcinosis, Cardiovascular Diseases, Diabetes Complications, Female, Femoral Artery, Fluorine Radioisotopes, Humans, Hypercholesterolemia, Hypertension, Male, Middle Aged, Multimodal Imaging, Neoplasms, Positron-Emission Tomography, Prevalence, Reproducibility of Results, Risk Factors, Smoking, Sodium Fluoride, Tomography, X-Ray Computed, Young Adult",

author = "Tido Janssen and Peter Bannas and Jochen Herrmann and Simon Veldhoen and Busch, {Jasmin D} and Andr{\'a}s Treszl and Silvia M{\"u}nster and Janos Mester and Thorsten Derlin",

year = "2013",

month = aug,

day = "1",

doi = "10.1007/s12350-013-9680-8",

language = "English",

volume = "20",

pages = "569--77",

journal = "J NUCL CARDIOL",

issn = "1071-3581",

publisher = "Springer New York",

number = "4",

}

RIS

TY - JOUR

T1 - Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors

T2 - a PET/CT study

AU - Janssen, Tido

AU - Bannas, Peter

AU - Herrmann, Jochen

AU - Veldhoen, Simon

AU - Busch, Jasmin D

AU - Treszl, András

AU - Münster, Silvia

AU - Mester, Janos

AU - Derlin, Thorsten

PY - 2013/8/1

Y1 - 2013/8/1

N2 - BACKGROUND: The aim of this study was to correlate linear (18)F-sodium fluoride accumulation in the femoral arteries as a measure of diffuse mineral deposition in medial elastocalcinosis with cardiovascular risk factors (RFs) and calcified plaque burden (CPB).METHODS AND RESULTS: In this study, 409 patients were examined by (18)F-sodium fluoride positron emission tomography/computed tomography (PET/CT). Tracer accumulation was analyzed both qualitatively and semiquantitatively by measuring the target-to-background ratio, and compared with cardiovascular RFs and CPB. Linear (18)F-sodium fluoride accumulation was observed in 159 (38.9%) patients and correlated significantly with age (P < .0001), hypertension (P < .0001), hypercholesterolemia (P = .0003), diabetes (P = .0003), history of smoking (P = .0007), prior cardiovascular events (P = .03), and CPB (P < .0001). The prevalence of linear tracer uptake increased as the number of cardiovascular RFs increased (P < .0001).CONCLUSIONS: Linear (18)F-sodium fluoride uptake in the femoral arteries (1) provides a measure of diffuse mineral deposition, (2) demonstrates a highly significant correlation with cardiovascular RFs and CPB, and (3) is found to accumulate more frequently in patients with a high-risk profile for cardiovascular events. (18)F-sodium fluoride PET/CT may become a unique tool for in vivo visualization and quantification of ongoing calcification in large arteries.

AB - BACKGROUND: The aim of this study was to correlate linear (18)F-sodium fluoride accumulation in the femoral arteries as a measure of diffuse mineral deposition in medial elastocalcinosis with cardiovascular risk factors (RFs) and calcified plaque burden (CPB).METHODS AND RESULTS: In this study, 409 patients were examined by (18)F-sodium fluoride positron emission tomography/computed tomography (PET/CT). Tracer accumulation was analyzed both qualitatively and semiquantitatively by measuring the target-to-background ratio, and compared with cardiovascular RFs and CPB. Linear (18)F-sodium fluoride accumulation was observed in 159 (38.9%) patients and correlated significantly with age (P < .0001), hypertension (P < .0001), hypercholesterolemia (P = .0003), diabetes (P = .0003), history of smoking (P = .0007), prior cardiovascular events (P = .03), and CPB (P < .0001). The prevalence of linear tracer uptake increased as the number of cardiovascular RFs increased (P < .0001).CONCLUSIONS: Linear (18)F-sodium fluoride uptake in the femoral arteries (1) provides a measure of diffuse mineral deposition, (2) demonstrates a highly significant correlation with cardiovascular RFs and CPB, and (3) is found to accumulate more frequently in patients with a high-risk profile for cardiovascular events. (18)F-sodium fluoride PET/CT may become a unique tool for in vivo visualization and quantification of ongoing calcification in large arteries.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Calcinosis

KW - Cardiovascular Diseases

KW - Diabetes Complications

KW - Female

KW - Femoral Artery

KW - Fluorine Radioisotopes

KW - Humans

KW - Hypercholesterolemia

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Multimodal Imaging

KW - Neoplasms

KW - Positron-Emission Tomography

KW - Prevalence

KW - Reproducibility of Results

KW - Risk Factors

KW - Smoking

KW - Sodium Fluoride

KW - Tomography, X-Ray Computed

KW - Young Adult

U2 - 10.1007/s12350-013-9680-8

DO - 10.1007/s12350-013-9680-8

M3 - SCORING: Journal article

C2 - 23588862

VL - 20

SP - 569

EP - 577

JO - J NUCL CARDIOL

JF - J NUCL CARDIOL

SN - 1071-3581

IS - 4

ER -