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Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study

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Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study. / Sinning, Christoph; Keller, Till; Zeller, Tanja; Ojeda, Francisco; Schlüter, Michael; Schnabel, Renate; Lubos, Edith; Bickel, Christoph; Lackner, Karl J; Diemert, Patrick; Munzel, Thomas; Blankenberg, Stefan; Wild, Philipp S; Gutenberg Health Study investigators.

In: CLIN RES CARDIOL, Vol. 103, No. 3, 03.2014, p. 211-222.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sinning, C, Keller, T, Zeller, T, Ojeda, F, Schlüter, M, Schnabel, R, Lubos, E, Bickel, C, Lackner, KJ, Diemert, P, Munzel, T, Blankenberg, S, Wild, PS & Gutenberg Health Study investigators 2014, 'Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study', CLIN RES CARDIOL, vol. 103, no. 3, pp. 211-222. https://doi.org/10.1007/s00392-013-0640-8

APA

Sinning, C., Keller, T., Zeller, T., Ojeda, F., Schlüter, M., Schnabel, R., Lubos, E., Bickel, C., Lackner, K. J., Diemert, P., Munzel, T., Blankenberg, S., Wild, P. S., & Gutenberg Health Study investigators (2014). Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study. CLIN RES CARDIOL, 103(3), 211-222. https://doi.org/10.1007/s00392-013-0640-8

Vancouver

Sinning C, Keller T, Zeller T, Ojeda F, Schlüter M, Schnabel R et al. Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study. CLIN RES CARDIOL. 2014 Mar;103(3):211-222. https://doi.org/10.1007/s00392-013-0640-8

Bibtex

@article{fd50097d6c1f42bb9925e2b59719a0eb,
title = "Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study",
abstract = "BACKGROUND: Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.METHODS: In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35-74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.RESULTS: In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3% overall, 89.9% men (N = 1,888), 74.4% women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E' correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.CONCLUSIONS: Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.",
keywords = "Adult, Biomarkers/blood, Cardiovascular Diseases/blood, Carotid Artery Diseases/blood, Carotid Intima-Media Thickness, Echocardiography, Doppler, Female, Germany/epidemiology, Health Surveys, Humans, Hypertrophy, Left Ventricular/blood, Limit of Detection, Male, Middle Aged, Phenotype, Predictive Value of Tests, Stroke Volume, Troponin I/blood, Vascular Stiffness, Ventricular Function, Left",
author = "Christoph Sinning and Till Keller and Tanja Zeller and Francisco Ojeda and Michael Schl{\"u}ter and Renate Schnabel and Edith Lubos and Christoph Bickel and Lackner, {Karl J} and Patrick Diemert and Thomas Munzel and Stefan Blankenberg and Wild, {Philipp S} and {Gutenberg Health Study investigators}",
year = "2014",
month = mar,
doi = "10.1007/s00392-013-0640-8",
language = "English",
volume = "103",
pages = "211--222",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study

AU - Sinning, Christoph

AU - Keller, Till

AU - Zeller, Tanja

AU - Ojeda, Francisco

AU - Schlüter, Michael

AU - Schnabel, Renate

AU - Lubos, Edith

AU - Bickel, Christoph

AU - Lackner, Karl J

AU - Diemert, Patrick

AU - Munzel, Thomas

AU - Blankenberg, Stefan

AU - Wild, Philipp S

AU - Gutenberg Health Study investigators

PY - 2014/3

Y1 - 2014/3

N2 - BACKGROUND: Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.METHODS: In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35-74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.RESULTS: In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3% overall, 89.9% men (N = 1,888), 74.4% women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E' correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.CONCLUSIONS: Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.

AB - BACKGROUND: Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.METHODS: In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35-74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.RESULTS: In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3% overall, 89.9% men (N = 1,888), 74.4% women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E' correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.CONCLUSIONS: Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.

KW - Adult

KW - Biomarkers/blood

KW - Cardiovascular Diseases/blood

KW - Carotid Artery Diseases/blood

KW - Carotid Intima-Media Thickness

KW - Echocardiography, Doppler

KW - Female

KW - Germany/epidemiology

KW - Health Surveys

KW - Humans

KW - Hypertrophy, Left Ventricular/blood

KW - Limit of Detection

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Predictive Value of Tests

KW - Stroke Volume

KW - Troponin I/blood

KW - Vascular Stiffness

KW - Ventricular Function, Left

U2 - 10.1007/s00392-013-0640-8

DO - 10.1007/s00392-013-0640-8

M3 - SCORING: Journal article

C2 - 24271361

VL - 103

SP - 211

EP - 222

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 3

ER -