Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study
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Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study. / Sinning, Christoph; Keller, Till; Zeller, Tanja; Ojeda, Francisco; Schlüter, Michael; Schnabel, Renate; Lubos, Edith; Bickel, Christoph; Lackner, Karl J; Diemert, Patrick; Munzel, Thomas; Blankenberg, Stefan; Wild, Philipp S; Gutenberg Health Study investigators.
in: CLIN RES CARDIOL, Jahrgang 103, Nr. 3, 03.2014, S. 211-222.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study
AU - Sinning, Christoph
AU - Keller, Till
AU - Zeller, Tanja
AU - Ojeda, Francisco
AU - Schlüter, Michael
AU - Schnabel, Renate
AU - Lubos, Edith
AU - Bickel, Christoph
AU - Lackner, Karl J
AU - Diemert, Patrick
AU - Munzel, Thomas
AU - Blankenberg, Stefan
AU - Wild, Philipp S
AU - Gutenberg Health Study investigators
PY - 2014/3
Y1 - 2014/3
N2 - BACKGROUND: Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.METHODS: In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35-74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.RESULTS: In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3% overall, 89.9% men (N = 1,888), 74.4% women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E' correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.CONCLUSIONS: Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.
AB - BACKGROUND: Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.METHODS: In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35-74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.RESULTS: In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3% overall, 89.9% men (N = 1,888), 74.4% women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E' correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.CONCLUSIONS: Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.
KW - Adult
KW - Biomarkers/blood
KW - Cardiovascular Diseases/blood
KW - Carotid Artery Diseases/blood
KW - Carotid Intima-Media Thickness
KW - Echocardiography, Doppler
KW - Female
KW - Germany/epidemiology
KW - Health Surveys
KW - Humans
KW - Hypertrophy, Left Ventricular/blood
KW - Limit of Detection
KW - Male
KW - Middle Aged
KW - Phenotype
KW - Predictive Value of Tests
KW - Stroke Volume
KW - Troponin I/blood
KW - Vascular Stiffness
KW - Ventricular Function, Left
U2 - 10.1007/s00392-013-0640-8
DO - 10.1007/s00392-013-0640-8
M3 - SCORING: Journal article
C2 - 24271361
VL - 103
SP - 211
EP - 222
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 3
ER -