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Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis

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Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis. / Lukasz, Alexander; Hoffmeister, Bodo; Graf, Barbara; Wölk, Benno; Noeckler, Karsten; Bode-Böger, Stefanie M; Hadem, Johannes; Pischke, Sven; Kielstein, Jan T.

In: PLOS ONE, Vol. 9, No. 1, 01.01.2014, p. e87490.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lukasz, A, Hoffmeister, B, Graf, B, Wölk, B, Noeckler, K, Bode-Böger, SM, Hadem, J, Pischke, S & Kielstein, JT 2014, 'Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis', PLOS ONE, vol. 9, no. 1, pp. e87490. https://doi.org/10.1371/journal.pone.0087490

APA

Lukasz, A., Hoffmeister, B., Graf, B., Wölk, B., Noeckler, K., Bode-Böger, S. M., Hadem, J., Pischke, S., & Kielstein, J. T. (2014). Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis. PLOS ONE, 9(1), e87490. https://doi.org/10.1371/journal.pone.0087490

Vancouver

Lukasz A, Hoffmeister B, Graf B, Wölk B, Noeckler K, Bode-Böger SM et al. Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis. PLOS ONE. 2014 Jan 1;9(1):e87490. https://doi.org/10.1371/journal.pone.0087490

Bibtex

@article{916df5adaa95446ea9ca58647160d5f8,
title = "Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis",
abstract = "Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied recently in the context of sepsis and MODS showing potential to determine disease severity and outcome specific parameters like acute kidney injury (AKI) and survival. These biomarkers were measured in 13 patients with leptospirosis. High levels of Angpt-2 were statistically significant associated with a complicated clinical course with occurrence of AKI, Sepsis and intensive care unit treatment. ADMA was significantly associated with occurrence of AKI and ICU treatment whereas SDMA was associated with AKI. Therefore these endothelial markers may serve as additional tools for risk stratification in these patients.",
keywords = "Acute Kidney Injury, Adult, Angiopoietin-2, Arginine, Biological Markers, Female, Humans, Inflammation, Intensive Care Units, Leptospirosis, Male, Middle Aged, Sepsis, Severity of Illness Index",
author = "Alexander Lukasz and Bodo Hoffmeister and Barbara Graf and Benno W{\"o}lk and Karsten Noeckler and Bode-B{\"o}ger, {Stefanie M} and Johannes Hadem and Sven Pischke and Kielstein, {Jan T}",
year = "2014",
month = jan,
day = "1",
doi = "10.1371/journal.pone.0087490",
language = "English",
volume = "9",
pages = "e87490",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis

AU - Lukasz, Alexander

AU - Hoffmeister, Bodo

AU - Graf, Barbara

AU - Wölk, Benno

AU - Noeckler, Karsten

AU - Bode-Böger, Stefanie M

AU - Hadem, Johannes

AU - Pischke, Sven

AU - Kielstein, Jan T

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied recently in the context of sepsis and MODS showing potential to determine disease severity and outcome specific parameters like acute kidney injury (AKI) and survival. These biomarkers were measured in 13 patients with leptospirosis. High levels of Angpt-2 were statistically significant associated with a complicated clinical course with occurrence of AKI, Sepsis and intensive care unit treatment. ADMA was significantly associated with occurrence of AKI and ICU treatment whereas SDMA was associated with AKI. Therefore these endothelial markers may serve as additional tools for risk stratification in these patients.

AB - Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied recently in the context of sepsis and MODS showing potential to determine disease severity and outcome specific parameters like acute kidney injury (AKI) and survival. These biomarkers were measured in 13 patients with leptospirosis. High levels of Angpt-2 were statistically significant associated with a complicated clinical course with occurrence of AKI, Sepsis and intensive care unit treatment. ADMA was significantly associated with occurrence of AKI and ICU treatment whereas SDMA was associated with AKI. Therefore these endothelial markers may serve as additional tools for risk stratification in these patients.

KW - Acute Kidney Injury

KW - Adult

KW - Angiopoietin-2

KW - Arginine

KW - Biological Markers

KW - Female

KW - Humans

KW - Inflammation

KW - Intensive Care Units

KW - Leptospirosis

KW - Male

KW - Middle Aged

KW - Sepsis

KW - Severity of Illness Index

U2 - 10.1371/journal.pone.0087490

DO - 10.1371/journal.pone.0087490

M3 - SCORING: Journal article

C2 - 24498116

VL - 9

SP - e87490

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 1

ER -