Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis
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Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis. / Lukasz, Alexander; Hoffmeister, Bodo; Graf, Barbara; Wölk, Benno; Noeckler, Karsten; Bode-Böger, Stefanie M; Hadem, Johannes; Pischke, Sven; Kielstein, Jan T.
in: PLOS ONE, Jahrgang 9, Nr. 1, 01.01.2014, S. e87490.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis
AU - Lukasz, Alexander
AU - Hoffmeister, Bodo
AU - Graf, Barbara
AU - Wölk, Benno
AU - Noeckler, Karsten
AU - Bode-Böger, Stefanie M
AU - Hadem, Johannes
AU - Pischke, Sven
AU - Kielstein, Jan T
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied recently in the context of sepsis and MODS showing potential to determine disease severity and outcome specific parameters like acute kidney injury (AKI) and survival. These biomarkers were measured in 13 patients with leptospirosis. High levels of Angpt-2 were statistically significant associated with a complicated clinical course with occurrence of AKI, Sepsis and intensive care unit treatment. ADMA was significantly associated with occurrence of AKI and ICU treatment whereas SDMA was associated with AKI. Therefore these endothelial markers may serve as additional tools for risk stratification in these patients.
AB - Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied recently in the context of sepsis and MODS showing potential to determine disease severity and outcome specific parameters like acute kidney injury (AKI) and survival. These biomarkers were measured in 13 patients with leptospirosis. High levels of Angpt-2 were statistically significant associated with a complicated clinical course with occurrence of AKI, Sepsis and intensive care unit treatment. ADMA was significantly associated with occurrence of AKI and ICU treatment whereas SDMA was associated with AKI. Therefore these endothelial markers may serve as additional tools for risk stratification in these patients.
KW - Acute Kidney Injury
KW - Adult
KW - Angiopoietin-2
KW - Arginine
KW - Biological Markers
KW - Female
KW - Humans
KW - Inflammation
KW - Intensive Care Units
KW - Leptospirosis
KW - Male
KW - Middle Aged
KW - Sepsis
KW - Severity of Illness Index
U2 - 10.1371/journal.pone.0087490
DO - 10.1371/journal.pone.0087490
M3 - SCORING: Journal article
C2 - 24498116
VL - 9
SP - e87490
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 1
ER -