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Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium

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Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium. / Obermayr, Eva; Braicu, Elena Ioana; Polterauer, Stephan; Loverix, Liselore; Concin, Nicole; Woelber, Linn; Mahner, Sven; Sehouli, Jalid; Van Gorp, Toon; Vergote, Ignace; Zeillinger, Robert; Aust, Stefanie.

In: CANCERS, Vol. 13, No. 23, 5865, 23.11.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Obermayr, E, Braicu, EI, Polterauer, S, Loverix, L, Concin, N, Woelber, L, Mahner, S, Sehouli, J, Van Gorp, T, Vergote, I, Zeillinger, R & Aust, S 2021, 'Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium', CANCERS, vol. 13, no. 23, 5865. https://doi.org/10.3390/cancers13235865

APA

Obermayr, E., Braicu, E. I., Polterauer, S., Loverix, L., Concin, N., Woelber, L., Mahner, S., Sehouli, J., Van Gorp, T., Vergote, I., Zeillinger, R., & Aust, S. (2021). Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium. CANCERS, 13(23), [5865]. https://doi.org/10.3390/cancers13235865

Vancouver

Obermayr E, Braicu EI, Polterauer S, Loverix L, Concin N, Woelber L et al. Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium. CANCERS. 2021 Nov 23;13(23). 5865. https://doi.org/10.3390/cancers13235865

Bibtex

@article{24586c48d57d464cbef7e5829712c883,
title = "Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium",
abstract = "We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to tryptophan ratio (Kyn/Trp) as well as the CTC-related marker cyclophilin C (PPIC) were obtained before primary therapy and were correlated to the respective clinical and outcome data. The information provided by albumin and Kyn/Trp was integrated in a combined score for cancer exhaustion (CCES). A high CCES characterized by hypoalbuminemia and a high Kyn/Trp was associated with both decreased overall and progression-free survival, independent from other known prognostic factors in a multivariable analysis. The presence of PPIC-positive CTCs was significantly associated with a high CCES, highlighting that the interplay between the systemic microenvironment and CTCs should be considered in {"}liquid biopsy{"} biomarker assessment.",
author = "Eva Obermayr and Braicu, {Elena Ioana} and Stephan Polterauer and Liselore Loverix and Nicole Concin and Linn Woelber and Sven Mahner and Jalid Sehouli and {Van Gorp}, Toon and Ignace Vergote and Robert Zeillinger and Stefanie Aust",
year = "2021",
month = nov,
day = "23",
doi = "10.3390/cancers13235865",
language = "English",
volume = "13",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "23",

}

RIS

TY - JOUR

T1 - Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium

AU - Obermayr, Eva

AU - Braicu, Elena Ioana

AU - Polterauer, Stephan

AU - Loverix, Liselore

AU - Concin, Nicole

AU - Woelber, Linn

AU - Mahner, Sven

AU - Sehouli, Jalid

AU - Van Gorp, Toon

AU - Vergote, Ignace

AU - Zeillinger, Robert

AU - Aust, Stefanie

PY - 2021/11/23

Y1 - 2021/11/23

N2 - We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to tryptophan ratio (Kyn/Trp) as well as the CTC-related marker cyclophilin C (PPIC) were obtained before primary therapy and were correlated to the respective clinical and outcome data. The information provided by albumin and Kyn/Trp was integrated in a combined score for cancer exhaustion (CCES). A high CCES characterized by hypoalbuminemia and a high Kyn/Trp was associated with both decreased overall and progression-free survival, independent from other known prognostic factors in a multivariable analysis. The presence of PPIC-positive CTCs was significantly associated with a high CCES, highlighting that the interplay between the systemic microenvironment and CTCs should be considered in "liquid biopsy" biomarker assessment.

AB - We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to tryptophan ratio (Kyn/Trp) as well as the CTC-related marker cyclophilin C (PPIC) were obtained before primary therapy and were correlated to the respective clinical and outcome data. The information provided by albumin and Kyn/Trp was integrated in a combined score for cancer exhaustion (CCES). A high CCES characterized by hypoalbuminemia and a high Kyn/Trp was associated with both decreased overall and progression-free survival, independent from other known prognostic factors in a multivariable analysis. The presence of PPIC-positive CTCs was significantly associated with a high CCES, highlighting that the interplay between the systemic microenvironment and CTCs should be considered in "liquid biopsy" biomarker assessment.

U2 - 10.3390/cancers13235865

DO - 10.3390/cancers13235865

M3 - SCORING: Journal article

C2 - 34884980

VL - 13

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 23

M1 - 5865

ER -