Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium
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Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium. / Obermayr, Eva; Braicu, Elena Ioana; Polterauer, Stephan; Loverix, Liselore; Concin, Nicole; Woelber, Linn; Mahner, Sven; Sehouli, Jalid; Van Gorp, Toon; Vergote, Ignace; Zeillinger, Robert; Aust, Stefanie.
in: CANCERS, Jahrgang 13, Nr. 23, 5865, 23.11.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium
AU - Obermayr, Eva
AU - Braicu, Elena Ioana
AU - Polterauer, Stephan
AU - Loverix, Liselore
AU - Concin, Nicole
AU - Woelber, Linn
AU - Mahner, Sven
AU - Sehouli, Jalid
AU - Van Gorp, Toon
AU - Vergote, Ignace
AU - Zeillinger, Robert
AU - Aust, Stefanie
PY - 2021/11/23
Y1 - 2021/11/23
N2 - We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to tryptophan ratio (Kyn/Trp) as well as the CTC-related marker cyclophilin C (PPIC) were obtained before primary therapy and were correlated to the respective clinical and outcome data. The information provided by albumin and Kyn/Trp was integrated in a combined score for cancer exhaustion (CCES). A high CCES characterized by hypoalbuminemia and a high Kyn/Trp was associated with both decreased overall and progression-free survival, independent from other known prognostic factors in a multivariable analysis. The presence of PPIC-positive CTCs was significantly associated with a high CCES, highlighting that the interplay between the systemic microenvironment and CTCs should be considered in "liquid biopsy" biomarker assessment.
AB - We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to tryptophan ratio (Kyn/Trp) as well as the CTC-related marker cyclophilin C (PPIC) were obtained before primary therapy and were correlated to the respective clinical and outcome data. The information provided by albumin and Kyn/Trp was integrated in a combined score for cancer exhaustion (CCES). A high CCES characterized by hypoalbuminemia and a high Kyn/Trp was associated with both decreased overall and progression-free survival, independent from other known prognostic factors in a multivariable analysis. The presence of PPIC-positive CTCs was significantly associated with a high CCES, highlighting that the interplay between the systemic microenvironment and CTCs should be considered in "liquid biopsy" biomarker assessment.
U2 - 10.3390/cancers13235865
DO - 10.3390/cancers13235865
M3 - SCORING: Journal article
C2 - 34884980
VL - 13
JO - CANCERS
JF - CANCERS
SN - 2072-6694
IS - 23
M1 - 5865
ER -