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Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer

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Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer. / Piccinelli, Mattia Luca; Luzzago, Stefano; Marvaso, Giulia; Laukhtina, Ekaterina; Miura, Noriyoshi; Schuettfort, Victor M; Mori, Keiichiro; Colombo, Alberto; Ferro, Matteo; Mistretta, Francesco A; Fusco, Nicola; Petralia, Giuseppe; Jereczek-Fossa, Barbara A; Shariat, Shahrokh F; Karakiewicz, Pierre I; de Cobelli, Ottavio; Musi, Gennaro.

In: WORLD J UROL, Vol. 40, No. 6, 06.2022, p. 1447-1454.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Piccinelli, ML, Luzzago, S, Marvaso, G, Laukhtina, E, Miura, N, Schuettfort, VM, Mori, K, Colombo, A, Ferro, M, Mistretta, FA, Fusco, N, Petralia, G, Jereczek-Fossa, BA, Shariat, SF, Karakiewicz, PI, de Cobelli, O & Musi, G 2022, 'Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer', WORLD J UROL, vol. 40, no. 6, pp. 1447-1454. https://doi.org/10.1007/s00345-022-03983-8

APA

Piccinelli, M. L., Luzzago, S., Marvaso, G., Laukhtina, E., Miura, N., Schuettfort, V. M., Mori, K., Colombo, A., Ferro, M., Mistretta, F. A., Fusco, N., Petralia, G., Jereczek-Fossa, B. A., Shariat, S. F., Karakiewicz, P. I., de Cobelli, O., & Musi, G. (2022). Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer. WORLD J UROL, 40(6), 1447-1454. https://doi.org/10.1007/s00345-022-03983-8

Vancouver

Piccinelli ML, Luzzago S, Marvaso G, Laukhtina E, Miura N, Schuettfort VM et al. Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer. WORLD J UROL. 2022 Jun;40(6):1447-1454. https://doi.org/10.1007/s00345-022-03983-8

Bibtex

@article{0e7ae725b4be459591f778554c37ef77,
title = "Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer",
abstract = "PURPOSE: To test any-cause discontinuation and ISUP GG upgrading rates during Active Surveillance (AS) in patients that underwent previous negative biopsies (PNBs) before prostate cancer (PCa) diagnosis vs. biopsy naive patients.METHODS: Retrospective analysis of 961 AS patients (2008-2020). Three definitions of PNBs were used: (1) PNBs status (biopsy na{\"i}ve vs. PNBs); (2) number of PNBs (0 vs. 1 vs. ≥ 2); (3) histology at last PNB (no vs. negative vs. HGPIN/ASAP). Kaplan-Meier plots and multivariable Cox models tested any-cause and ISUP GG upgrading discontinuation rates.RESULTS: Overall, 760 (79.1%) vs. 201 (20.9%) patients were biopsy na{\"i}ve vs. PNBs. Specifically, 760 (79.1%) vs. 138 (14.4%) vs. 63 (6.5%) patients had 0 vs. 1 vs. ≥ 2 PNBs. Last, 760 (79.1%) vs. 134 (13.9%) vs. 67 (7%) patients had no vs. negative PNB vs. HGPIN/ASAP. PNBs were not associated with any-cause discontinuation rates. Conversely, PNBs were associated with lower rates of ISUP GG upgrading: (1) PNBs vs. biopsy na{\"i}ve (HR:0.6, p = 0.04); (2) 1 vs. 0 PNBs (HR:0.6, p = 0.1) and 2 vs. 0 PNBs, (HR:0.5, p = 0.1); (3) negative PNB vs. biopsy na{\"i}ve (HR:0.7, p = 0.3) and HGPIN/ASAP vs. biopsy na{\"i}ve (HR:0.4, p = 0.04). However, last PNB ≤ 18 months (HR:0.4, p = 0.02), but not last PNB > 18 months (HR:0.8, p = 0.5) were associated with lower rates of ISUP GG upgrading.CONCLUSION: PNBs status is associated with lower rates of ISUP GG upgrading during AS for PCa. The number of PNBs and time from last PNB to PCa diagnosis (≤ 18 months) appear also to be critical for patient selection.",
keywords = "Biopsy, Humans, Male, Prostatic Intraepithelial Neoplasia, Prostatic Neoplasms/diagnosis, Retrospective Studies, Watchful Waiting",
author = "Piccinelli, {Mattia Luca} and Stefano Luzzago and Giulia Marvaso and Ekaterina Laukhtina and Noriyoshi Miura and Schuettfort, {Victor M} and Keiichiro Mori and Alberto Colombo and Matteo Ferro and Mistretta, {Francesco A} and Nicola Fusco and Giuseppe Petralia and Jereczek-Fossa, {Barbara A} and Shariat, {Shahrokh F} and Karakiewicz, {Pierre I} and {de Cobelli}, Ottavio and Gennaro Musi",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = jun,
doi = "10.1007/s00345-022-03983-8",
language = "English",
volume = "40",
pages = "1447--1454",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer

AU - Piccinelli, Mattia Luca

AU - Luzzago, Stefano

AU - Marvaso, Giulia

AU - Laukhtina, Ekaterina

AU - Miura, Noriyoshi

AU - Schuettfort, Victor M

AU - Mori, Keiichiro

AU - Colombo, Alberto

AU - Ferro, Matteo

AU - Mistretta, Francesco A

AU - Fusco, Nicola

AU - Petralia, Giuseppe

AU - Jereczek-Fossa, Barbara A

AU - Shariat, Shahrokh F

AU - Karakiewicz, Pierre I

AU - de Cobelli, Ottavio

AU - Musi, Gennaro

N1 - © 2022. The Author(s).

PY - 2022/6

Y1 - 2022/6

N2 - PURPOSE: To test any-cause discontinuation and ISUP GG upgrading rates during Active Surveillance (AS) in patients that underwent previous negative biopsies (PNBs) before prostate cancer (PCa) diagnosis vs. biopsy naive patients.METHODS: Retrospective analysis of 961 AS patients (2008-2020). Three definitions of PNBs were used: (1) PNBs status (biopsy naïve vs. PNBs); (2) number of PNBs (0 vs. 1 vs. ≥ 2); (3) histology at last PNB (no vs. negative vs. HGPIN/ASAP). Kaplan-Meier plots and multivariable Cox models tested any-cause and ISUP GG upgrading discontinuation rates.RESULTS: Overall, 760 (79.1%) vs. 201 (20.9%) patients were biopsy naïve vs. PNBs. Specifically, 760 (79.1%) vs. 138 (14.4%) vs. 63 (6.5%) patients had 0 vs. 1 vs. ≥ 2 PNBs. Last, 760 (79.1%) vs. 134 (13.9%) vs. 67 (7%) patients had no vs. negative PNB vs. HGPIN/ASAP. PNBs were not associated with any-cause discontinuation rates. Conversely, PNBs were associated with lower rates of ISUP GG upgrading: (1) PNBs vs. biopsy naïve (HR:0.6, p = 0.04); (2) 1 vs. 0 PNBs (HR:0.6, p = 0.1) and 2 vs. 0 PNBs, (HR:0.5, p = 0.1); (3) negative PNB vs. biopsy naïve (HR:0.7, p = 0.3) and HGPIN/ASAP vs. biopsy naïve (HR:0.4, p = 0.04). However, last PNB ≤ 18 months (HR:0.4, p = 0.02), but not last PNB > 18 months (HR:0.8, p = 0.5) were associated with lower rates of ISUP GG upgrading.CONCLUSION: PNBs status is associated with lower rates of ISUP GG upgrading during AS for PCa. The number of PNBs and time from last PNB to PCa diagnosis (≤ 18 months) appear also to be critical for patient selection.

AB - PURPOSE: To test any-cause discontinuation and ISUP GG upgrading rates during Active Surveillance (AS) in patients that underwent previous negative biopsies (PNBs) before prostate cancer (PCa) diagnosis vs. biopsy naive patients.METHODS: Retrospective analysis of 961 AS patients (2008-2020). Three definitions of PNBs were used: (1) PNBs status (biopsy naïve vs. PNBs); (2) number of PNBs (0 vs. 1 vs. ≥ 2); (3) histology at last PNB (no vs. negative vs. HGPIN/ASAP). Kaplan-Meier plots and multivariable Cox models tested any-cause and ISUP GG upgrading discontinuation rates.RESULTS: Overall, 760 (79.1%) vs. 201 (20.9%) patients were biopsy naïve vs. PNBs. Specifically, 760 (79.1%) vs. 138 (14.4%) vs. 63 (6.5%) patients had 0 vs. 1 vs. ≥ 2 PNBs. Last, 760 (79.1%) vs. 134 (13.9%) vs. 67 (7%) patients had no vs. negative PNB vs. HGPIN/ASAP. PNBs were not associated with any-cause discontinuation rates. Conversely, PNBs were associated with lower rates of ISUP GG upgrading: (1) PNBs vs. biopsy naïve (HR:0.6, p = 0.04); (2) 1 vs. 0 PNBs (HR:0.6, p = 0.1) and 2 vs. 0 PNBs, (HR:0.5, p = 0.1); (3) negative PNB vs. biopsy naïve (HR:0.7, p = 0.3) and HGPIN/ASAP vs. biopsy naïve (HR:0.4, p = 0.04). However, last PNB ≤ 18 months (HR:0.4, p = 0.02), but not last PNB > 18 months (HR:0.8, p = 0.5) were associated with lower rates of ISUP GG upgrading.CONCLUSION: PNBs status is associated with lower rates of ISUP GG upgrading during AS for PCa. The number of PNBs and time from last PNB to PCa diagnosis (≤ 18 months) appear also to be critical for patient selection.

KW - Biopsy

KW - Humans

KW - Male

KW - Prostatic Intraepithelial Neoplasia

KW - Prostatic Neoplasms/diagnosis

KW - Retrospective Studies

KW - Watchful Waiting

U2 - 10.1007/s00345-022-03983-8

DO - 10.1007/s00345-022-03983-8

M3 - SCORING: Journal article

C2 - 35347414

VL - 40

SP - 1447

EP - 1454

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 6

ER -