Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer
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Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer. / Piccinelli, Mattia Luca; Luzzago, Stefano; Marvaso, Giulia; Laukhtina, Ekaterina; Miura, Noriyoshi; Schuettfort, Victor M; Mori, Keiichiro; Colombo, Alberto; Ferro, Matteo; Mistretta, Francesco A; Fusco, Nicola; Petralia, Giuseppe; Jereczek-Fossa, Barbara A; Shariat, Shahrokh F; Karakiewicz, Pierre I; de Cobelli, Ottavio; Musi, Gennaro.
in: WORLD J UROL, Jahrgang 40, Nr. 6, 06.2022, S. 1447-1454.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Association between previous negative biopsies and lower rates of progression during active surveillance for prostate cancer
AU - Piccinelli, Mattia Luca
AU - Luzzago, Stefano
AU - Marvaso, Giulia
AU - Laukhtina, Ekaterina
AU - Miura, Noriyoshi
AU - Schuettfort, Victor M
AU - Mori, Keiichiro
AU - Colombo, Alberto
AU - Ferro, Matteo
AU - Mistretta, Francesco A
AU - Fusco, Nicola
AU - Petralia, Giuseppe
AU - Jereczek-Fossa, Barbara A
AU - Shariat, Shahrokh F
AU - Karakiewicz, Pierre I
AU - de Cobelli, Ottavio
AU - Musi, Gennaro
N1 - © 2022. The Author(s).
PY - 2022/6
Y1 - 2022/6
N2 - PURPOSE: To test any-cause discontinuation and ISUP GG upgrading rates during Active Surveillance (AS) in patients that underwent previous negative biopsies (PNBs) before prostate cancer (PCa) diagnosis vs. biopsy naive patients.METHODS: Retrospective analysis of 961 AS patients (2008-2020). Three definitions of PNBs were used: (1) PNBs status (biopsy naïve vs. PNBs); (2) number of PNBs (0 vs. 1 vs. ≥ 2); (3) histology at last PNB (no vs. negative vs. HGPIN/ASAP). Kaplan-Meier plots and multivariable Cox models tested any-cause and ISUP GG upgrading discontinuation rates.RESULTS: Overall, 760 (79.1%) vs. 201 (20.9%) patients were biopsy naïve vs. PNBs. Specifically, 760 (79.1%) vs. 138 (14.4%) vs. 63 (6.5%) patients had 0 vs. 1 vs. ≥ 2 PNBs. Last, 760 (79.1%) vs. 134 (13.9%) vs. 67 (7%) patients had no vs. negative PNB vs. HGPIN/ASAP. PNBs were not associated with any-cause discontinuation rates. Conversely, PNBs were associated with lower rates of ISUP GG upgrading: (1) PNBs vs. biopsy naïve (HR:0.6, p = 0.04); (2) 1 vs. 0 PNBs (HR:0.6, p = 0.1) and 2 vs. 0 PNBs, (HR:0.5, p = 0.1); (3) negative PNB vs. biopsy naïve (HR:0.7, p = 0.3) and HGPIN/ASAP vs. biopsy naïve (HR:0.4, p = 0.04). However, last PNB ≤ 18 months (HR:0.4, p = 0.02), but not last PNB > 18 months (HR:0.8, p = 0.5) were associated with lower rates of ISUP GG upgrading.CONCLUSION: PNBs status is associated with lower rates of ISUP GG upgrading during AS for PCa. The number of PNBs and time from last PNB to PCa diagnosis (≤ 18 months) appear also to be critical for patient selection.
AB - PURPOSE: To test any-cause discontinuation and ISUP GG upgrading rates during Active Surveillance (AS) in patients that underwent previous negative biopsies (PNBs) before prostate cancer (PCa) diagnosis vs. biopsy naive patients.METHODS: Retrospective analysis of 961 AS patients (2008-2020). Three definitions of PNBs were used: (1) PNBs status (biopsy naïve vs. PNBs); (2) number of PNBs (0 vs. 1 vs. ≥ 2); (3) histology at last PNB (no vs. negative vs. HGPIN/ASAP). Kaplan-Meier plots and multivariable Cox models tested any-cause and ISUP GG upgrading discontinuation rates.RESULTS: Overall, 760 (79.1%) vs. 201 (20.9%) patients were biopsy naïve vs. PNBs. Specifically, 760 (79.1%) vs. 138 (14.4%) vs. 63 (6.5%) patients had 0 vs. 1 vs. ≥ 2 PNBs. Last, 760 (79.1%) vs. 134 (13.9%) vs. 67 (7%) patients had no vs. negative PNB vs. HGPIN/ASAP. PNBs were not associated with any-cause discontinuation rates. Conversely, PNBs were associated with lower rates of ISUP GG upgrading: (1) PNBs vs. biopsy naïve (HR:0.6, p = 0.04); (2) 1 vs. 0 PNBs (HR:0.6, p = 0.1) and 2 vs. 0 PNBs, (HR:0.5, p = 0.1); (3) negative PNB vs. biopsy naïve (HR:0.7, p = 0.3) and HGPIN/ASAP vs. biopsy naïve (HR:0.4, p = 0.04). However, last PNB ≤ 18 months (HR:0.4, p = 0.02), but not last PNB > 18 months (HR:0.8, p = 0.5) were associated with lower rates of ISUP GG upgrading.CONCLUSION: PNBs status is associated with lower rates of ISUP GG upgrading during AS for PCa. The number of PNBs and time from last PNB to PCa diagnosis (≤ 18 months) appear also to be critical for patient selection.
KW - Biopsy
KW - Humans
KW - Male
KW - Prostatic Intraepithelial Neoplasia
KW - Prostatic Neoplasms/diagnosis
KW - Retrospective Studies
KW - Watchful Waiting
U2 - 10.1007/s00345-022-03983-8
DO - 10.1007/s00345-022-03983-8
M3 - SCORING: Journal article
C2 - 35347414
VL - 40
SP - 1447
EP - 1454
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 6
ER -