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Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis

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Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis. / Khuseyinova, Natalie; Imhof, Armin; Rothenbacher, Dietrich; Trischler, Gerlinde; Kuelb, Silke; Scharnagl, Hubert; Maerz, Winfried; Brenner, Hermann; Koenig, Wolfgang.

In: ATHEROSCLEROSIS, Vol. 182, No. 1, 09.2005, p. 181-188.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Khuseyinova, N, Imhof, A, Rothenbacher, D, Trischler, G, Kuelb, S, Scharnagl, H, Maerz, W, Brenner, H & Koenig, W 2005, 'Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis', ATHEROSCLEROSIS, vol. 182, no. 1, pp. 181-188. https://doi.org/10.1016/j.atherosclerosis.2004.10.046

APA

Khuseyinova, N., Imhof, A., Rothenbacher, D., Trischler, G., Kuelb, S., Scharnagl, H., Maerz, W., Brenner, H., & Koenig, W. (2005). Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis. ATHEROSCLEROSIS, 182(1), 181-188. https://doi.org/10.1016/j.atherosclerosis.2004.10.046

Vancouver

Khuseyinova N, Imhof A, Rothenbacher D, Trischler G, Kuelb S, Scharnagl H et al. Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis. ATHEROSCLEROSIS. 2005 Sep;182(1):181-188. https://doi.org/10.1016/j.atherosclerosis.2004.10.046

Bibtex

@article{16f41523da4a49578512cc82537104e5,
title = "Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis",
abstract = "Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD.",
keywords = "1-Alkyl-2-acetylglycerophosphocholine Esterase, Aged, Biomarkers/blood, Case-Control Studies, Coronary Artery Disease/blood, Female, Hemostasis/immunology, Humans, Lipoproteins/blood, Male, Middle Aged, Phospholipases A/blood, Phospholipases A2, Risk Factors, Severity of Illness Index",
author = "Natalie Khuseyinova and Armin Imhof and Dietrich Rothenbacher and Gerlinde Trischler and Silke Kuelb and Hubert Scharnagl and Winfried Maerz and Hermann Brenner and Wolfgang Koenig",
year = "2005",
month = sep,
doi = "10.1016/j.atherosclerosis.2004.10.046",
language = "English",
volume = "182",
pages = "181--188",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis

AU - Khuseyinova, Natalie

AU - Imhof, Armin

AU - Rothenbacher, Dietrich

AU - Trischler, Gerlinde

AU - Kuelb, Silke

AU - Scharnagl, Hubert

AU - Maerz, Winfried

AU - Brenner, Hermann

AU - Koenig, Wolfgang

PY - 2005/9

Y1 - 2005/9

N2 - Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD.

AB - Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD.

KW - 1-Alkyl-2-acetylglycerophosphocholine Esterase

KW - Aged

KW - Biomarkers/blood

KW - Case-Control Studies

KW - Coronary Artery Disease/blood

KW - Female

KW - Hemostasis/immunology

KW - Humans

KW - Lipoproteins/blood

KW - Male

KW - Middle Aged

KW - Phospholipases A/blood

KW - Phospholipases A2

KW - Risk Factors

KW - Severity of Illness Index

U2 - 10.1016/j.atherosclerosis.2004.10.046

DO - 10.1016/j.atherosclerosis.2004.10.046

M3 - SCORING: Journal article

C2 - 16115490

VL - 182

SP - 181

EP - 188

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

IS - 1

ER -