Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis
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Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis. / Khuseyinova, Natalie; Imhof, Armin; Rothenbacher, Dietrich; Trischler, Gerlinde; Kuelb, Silke; Scharnagl, Hubert; Maerz, Winfried; Brenner, Hermann; Koenig, Wolfgang.
in: ATHEROSCLEROSIS, Jahrgang 182, Nr. 1, 09.2005, S. 181-188.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung
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TY - JOUR
T1 - Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis
AU - Khuseyinova, Natalie
AU - Imhof, Armin
AU - Rothenbacher, Dietrich
AU - Trischler, Gerlinde
AU - Kuelb, Silke
AU - Scharnagl, Hubert
AU - Maerz, Winfried
AU - Brenner, Hermann
AU - Koenig, Wolfgang
PY - 2005/9
Y1 - 2005/9
N2 - Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD.
AB - Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD.
KW - 1-Alkyl-2-acetylglycerophosphocholine Esterase
KW - Aged
KW - Biomarkers/blood
KW - Case-Control Studies
KW - Coronary Artery Disease/blood
KW - Female
KW - Hemostasis/immunology
KW - Humans
KW - Lipoproteins/blood
KW - Male
KW - Middle Aged
KW - Phospholipases A/blood
KW - Phospholipases A2
KW - Risk Factors
KW - Severity of Illness Index
U2 - 10.1016/j.atherosclerosis.2004.10.046
DO - 10.1016/j.atherosclerosis.2004.10.046
M3 - SCORING: Journal article
C2 - 16115490
VL - 182
SP - 181
EP - 188
JO - ATHEROSCLEROSIS
JF - ATHEROSCLEROSIS
SN - 0021-9150
IS - 1
ER -