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Are Children the Better Placebo Analgesia Responders?: An Experimental Approach

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Are Children the Better Placebo Analgesia Responders?: An Experimental Approach. / Wrobel, Nathalie; Fadai, Tahmine; Sprenger, Christian; Hebebrand, Johannes; Wiech, Katja; Bingel, Ulrike.

In: J PAIN, Vol. 16, No. 10, 10.2015, p. 1005-11.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wrobel, N, Fadai, T, Sprenger, C, Hebebrand, J, Wiech, K & Bingel, U 2015, 'Are Children the Better Placebo Analgesia Responders?: An Experimental Approach', J PAIN, vol. 16, no. 10, pp. 1005-11. https://doi.org/10.1016/j.jpain.2015.06.013

APA

Wrobel, N., Fadai, T., Sprenger, C., Hebebrand, J., Wiech, K., & Bingel, U. (2015). Are Children the Better Placebo Analgesia Responders?: An Experimental Approach. J PAIN, 16(10), 1005-11. https://doi.org/10.1016/j.jpain.2015.06.013

Vancouver

Wrobel N, Fadai T, Sprenger C, Hebebrand J, Wiech K, Bingel U. Are Children the Better Placebo Analgesia Responders?: An Experimental Approach. J PAIN. 2015 Oct;16(10):1005-11. https://doi.org/10.1016/j.jpain.2015.06.013

Bibtex

@article{4d070ea5490c464287199141f924fcb9,
title = "Are Children the Better Placebo Analgesia Responders?: An Experimental Approach",
abstract = "UNLABELLED: There is little information regarding changes in placebo responsiveness with age, although first predictors of placebo responders such as psychological and physiological processes have been identified. Reviews and meta-analyses indicate that placebo response rates in randomized controlled trials (RCTs) are higher in children and adolescents compared with adults. As these studies cannot control for age-dependent differences in the natural course of the disease, biases might contribute to different placebo rates in RCTs. To avoid these biases, this study investigated age-related differences in placebo responsiveness between children and adults in a well-established experimental model of placebo analgesia combining classic conditioning and expectation. Our data confirm placebo analgesic responses in children, which did not differ in magnitude from those of adults. The influence of previous experience on subsequent treatment outcome was stronger in children than in adults, indicating an increased relevance of learning processes for treatment outcomes in children. Further studies are needed to understand the influence of treatment-related learning processes in children and adolescents, which might critically determine treatment responsiveness during adulthood.PERSPECTIVE: This study is the first to experimentally explore placebo analgesia and influences of previous experience on placebo responses in children compared with adults. We found comparable placebo responses in both groups and an increased relevance of learning processes for treatment outcomes in children.",
author = "Nathalie Wrobel and Tahmine Fadai and Christian Sprenger and Johannes Hebebrand and Katja Wiech and Ulrike Bingel",
note = "Copyright {\textcopyright} 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.",
year = "2015",
month = oct,
doi = "10.1016/j.jpain.2015.06.013",
language = "English",
volume = "16",
pages = "1005--11",
journal = "J PAIN",
issn = "1526-5900",
publisher = "Churchill Livingstone",
number = "10",

}

RIS

TY - JOUR

T1 - Are Children the Better Placebo Analgesia Responders?: An Experimental Approach

AU - Wrobel, Nathalie

AU - Fadai, Tahmine

AU - Sprenger, Christian

AU - Hebebrand, Johannes

AU - Wiech, Katja

AU - Bingel, Ulrike

N1 - Copyright © 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.

PY - 2015/10

Y1 - 2015/10

N2 - UNLABELLED: There is little information regarding changes in placebo responsiveness with age, although first predictors of placebo responders such as psychological and physiological processes have been identified. Reviews and meta-analyses indicate that placebo response rates in randomized controlled trials (RCTs) are higher in children and adolescents compared with adults. As these studies cannot control for age-dependent differences in the natural course of the disease, biases might contribute to different placebo rates in RCTs. To avoid these biases, this study investigated age-related differences in placebo responsiveness between children and adults in a well-established experimental model of placebo analgesia combining classic conditioning and expectation. Our data confirm placebo analgesic responses in children, which did not differ in magnitude from those of adults. The influence of previous experience on subsequent treatment outcome was stronger in children than in adults, indicating an increased relevance of learning processes for treatment outcomes in children. Further studies are needed to understand the influence of treatment-related learning processes in children and adolescents, which might critically determine treatment responsiveness during adulthood.PERSPECTIVE: This study is the first to experimentally explore placebo analgesia and influences of previous experience on placebo responses in children compared with adults. We found comparable placebo responses in both groups and an increased relevance of learning processes for treatment outcomes in children.

AB - UNLABELLED: There is little information regarding changes in placebo responsiveness with age, although first predictors of placebo responders such as psychological and physiological processes have been identified. Reviews and meta-analyses indicate that placebo response rates in randomized controlled trials (RCTs) are higher in children and adolescents compared with adults. As these studies cannot control for age-dependent differences in the natural course of the disease, biases might contribute to different placebo rates in RCTs. To avoid these biases, this study investigated age-related differences in placebo responsiveness between children and adults in a well-established experimental model of placebo analgesia combining classic conditioning and expectation. Our data confirm placebo analgesic responses in children, which did not differ in magnitude from those of adults. The influence of previous experience on subsequent treatment outcome was stronger in children than in adults, indicating an increased relevance of learning processes for treatment outcomes in children. Further studies are needed to understand the influence of treatment-related learning processes in children and adolescents, which might critically determine treatment responsiveness during adulthood.PERSPECTIVE: This study is the first to experimentally explore placebo analgesia and influences of previous experience on placebo responses in children compared with adults. We found comparable placebo responses in both groups and an increased relevance of learning processes for treatment outcomes in children.

U2 - 10.1016/j.jpain.2015.06.013

DO - 10.1016/j.jpain.2015.06.013

M3 - SCORING: Journal article

C2 - 26220308

VL - 16

SP - 1005

EP - 1011

JO - J PAIN

JF - J PAIN

SN - 1526-5900

IS - 10

ER -