Are Children the Better Placebo Analgesia Responders?: An Experimental Approach
Standard
Are Children the Better Placebo Analgesia Responders?: An Experimental Approach. / Wrobel, Nathalie; Fadai, Tahmine; Sprenger, Christian; Hebebrand, Johannes; Wiech, Katja; Bingel, Ulrike.
in: J PAIN, Jahrgang 16, Nr. 10, 10.2015, S. 1005-11.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Are Children the Better Placebo Analgesia Responders?: An Experimental Approach
AU - Wrobel, Nathalie
AU - Fadai, Tahmine
AU - Sprenger, Christian
AU - Hebebrand, Johannes
AU - Wiech, Katja
AU - Bingel, Ulrike
N1 - Copyright © 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.
PY - 2015/10
Y1 - 2015/10
N2 - UNLABELLED: There is little information regarding changes in placebo responsiveness with age, although first predictors of placebo responders such as psychological and physiological processes have been identified. Reviews and meta-analyses indicate that placebo response rates in randomized controlled trials (RCTs) are higher in children and adolescents compared with adults. As these studies cannot control for age-dependent differences in the natural course of the disease, biases might contribute to different placebo rates in RCTs. To avoid these biases, this study investigated age-related differences in placebo responsiveness between children and adults in a well-established experimental model of placebo analgesia combining classic conditioning and expectation. Our data confirm placebo analgesic responses in children, which did not differ in magnitude from those of adults. The influence of previous experience on subsequent treatment outcome was stronger in children than in adults, indicating an increased relevance of learning processes for treatment outcomes in children. Further studies are needed to understand the influence of treatment-related learning processes in children and adolescents, which might critically determine treatment responsiveness during adulthood.PERSPECTIVE: This study is the first to experimentally explore placebo analgesia and influences of previous experience on placebo responses in children compared with adults. We found comparable placebo responses in both groups and an increased relevance of learning processes for treatment outcomes in children.
AB - UNLABELLED: There is little information regarding changes in placebo responsiveness with age, although first predictors of placebo responders such as psychological and physiological processes have been identified. Reviews and meta-analyses indicate that placebo response rates in randomized controlled trials (RCTs) are higher in children and adolescents compared with adults. As these studies cannot control for age-dependent differences in the natural course of the disease, biases might contribute to different placebo rates in RCTs. To avoid these biases, this study investigated age-related differences in placebo responsiveness between children and adults in a well-established experimental model of placebo analgesia combining classic conditioning and expectation. Our data confirm placebo analgesic responses in children, which did not differ in magnitude from those of adults. The influence of previous experience on subsequent treatment outcome was stronger in children than in adults, indicating an increased relevance of learning processes for treatment outcomes in children. Further studies are needed to understand the influence of treatment-related learning processes in children and adolescents, which might critically determine treatment responsiveness during adulthood.PERSPECTIVE: This study is the first to experimentally explore placebo analgesia and influences of previous experience on placebo responses in children compared with adults. We found comparable placebo responses in both groups and an increased relevance of learning processes for treatment outcomes in children.
U2 - 10.1016/j.jpain.2015.06.013
DO - 10.1016/j.jpain.2015.06.013
M3 - SCORING: Journal article
C2 - 26220308
VL - 16
SP - 1005
EP - 1011
JO - J PAIN
JF - J PAIN
SN - 1526-5900
IS - 10
ER -