Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks
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Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks. / Gao, Xiaoyan; Castro-Gomez, Sergio; Grendel, Jasper; Graf, Sabine; Süsens, Ute; Binkle, Lars; Mensching, Daniel; Isbrandt, Dirk; Kuhl, Dietmar; Ohana, Ora.
In: P NATL ACAD SCI USA, Vol. 115, No. 49, 04.12.2018, p. 12531-12536.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks
AU - Gao, Xiaoyan
AU - Castro-Gomez, Sergio
AU - Grendel, Jasper
AU - Graf, Sabine
AU - Süsens, Ute
AU - Binkle, Lars
AU - Mensching, Daniel
AU - Isbrandt, Dirk
AU - Kuhl, Dietmar
AU - Ohana, Ora
PY - 2018/12/4
Y1 - 2018/12/4
N2 - During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.
AB - During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.
KW - Journal Article
U2 - 10.1073/pnas.1810125115
DO - 10.1073/pnas.1810125115
M3 - SCORING: Journal article
C2 - 30442670
VL - 115
SP - 12531
EP - 12536
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 49
ER -