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Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks

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Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks. / Gao, Xiaoyan; Castro-Gomez, Sergio; Grendel, Jasper; Graf, Sabine; Süsens, Ute; Binkle, Lars; Mensching, Daniel; Isbrandt, Dirk; Kuhl, Dietmar; Ohana, Ora.

in: P NATL ACAD SCI USA, Jahrgang 115, Nr. 49, 04.12.2018, S. 12531-12536.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gao, X, Castro-Gomez, S, Grendel, J, Graf, S, Süsens, U, Binkle, L, Mensching, D, Isbrandt, D, Kuhl, D & Ohana, O 2018, 'Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks', P NATL ACAD SCI USA, Jg. 115, Nr. 49, S. 12531-12536. https://doi.org/10.1073/pnas.1810125115

APA

Gao, X., Castro-Gomez, S., Grendel, J., Graf, S., Süsens, U., Binkle, L., Mensching, D., Isbrandt, D., Kuhl, D., & Ohana, O. (2018). Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks. P NATL ACAD SCI USA, 115(49), 12531-12536. https://doi.org/10.1073/pnas.1810125115

Vancouver

Gao X, Castro-Gomez S, Grendel J, Graf S, Süsens U, Binkle L et al. Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks. P NATL ACAD SCI USA. 2018 Dez 4;115(49):12531-12536. https://doi.org/10.1073/pnas.1810125115

Bibtex

@article{cd9ae561e62748ab93dc5d5bf5751188,
title = "Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks",
abstract = "During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.",
keywords = "Journal Article",
author = "Xiaoyan Gao and Sergio Castro-Gomez and Jasper Grendel and Sabine Graf and Ute S{\"u}sens and Lars Binkle and Daniel Mensching and Dirk Isbrandt and Dietmar Kuhl and Ora Ohana",
year = "2018",
month = dec,
day = "4",
doi = "10.1073/pnas.1810125115",
language = "English",
volume = "115",
pages = "12531--12536",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "49",

}

RIS

TY - JOUR

T1 - Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks

AU - Gao, Xiaoyan

AU - Castro-Gomez, Sergio

AU - Grendel, Jasper

AU - Graf, Sabine

AU - Süsens, Ute

AU - Binkle, Lars

AU - Mensching, Daniel

AU - Isbrandt, Dirk

AU - Kuhl, Dietmar

AU - Ohana, Ora

PY - 2018/12/4

Y1 - 2018/12/4

N2 - During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.

AB - During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.

KW - Journal Article

U2 - 10.1073/pnas.1810125115

DO - 10.1073/pnas.1810125115

M3 - SCORING: Journal article

C2 - 30442670

VL - 115

SP - 12531

EP - 12536

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 49

ER -