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Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

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Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. / Liebold, Imke; Al Jawazneh, Amirah; Casar, Christian; Lanzloth, Clarissa; Leyk, Stephanie; Hamley, Madeleine; Wong, Milagros N; Kylies, Dominik; Gräfe, Stefanie K; Edenhofer, Ilka; Aranda-Pardos, Irene; Kriwet, Marie (Make Autor internal); Haas, Helmuth; Krause, Jenny; Hadjilaou, Alexandros; Schromm, Andra B; Richardt, Ulricke; Eggert, Petra; Tappe, Dennis; Weidemann, Sören A; Ghosh, Sourav; Krebs, Christian F; A-Gonzalez, Noelia; Worthmann, Anna; Lohse, Ansgar W; Huber, Samuel; Rothlin, Carla V; Puelles, Victor G; Jacobs, Thomas; Gagliani, Nicola; Bosurgi, Lidia.

In: SCIENCE, Vol. 384, No. 6691, 05.04.2024, p. eabo7027.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Liebold, I, Al Jawazneh, A, Casar, C, Lanzloth, C, Leyk, S, Hamley, M, Wong, MN, Kylies, D, Gräfe, SK, Edenhofer, I, Aranda-Pardos, I, Kriwet, M, Haas, H, Krause, J, Hadjilaou, A, Schromm, AB, Richardt, U, Eggert, P, Tappe, D, Weidemann, SA, Ghosh, S, Krebs, CF, A-Gonzalez, N, Worthmann, A, Lohse, AW, Huber, S, Rothlin, CV, Puelles, VG, Jacobs, T, Gagliani, N & Bosurgi, L 2024, 'Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages', SCIENCE, vol. 384, no. 6691, pp. eabo7027. https://doi.org/10.1126/science.abo7027

APA

Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., Aranda-Pardos, I., Kriwet, M., Haas, H., Krause, J., Hadjilaou, A., Schromm, A. B., Richardt, U., Eggert, P., Tappe, D., ... Bosurgi, L. (2024). Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. SCIENCE, 384(6691), eabo7027. https://doi.org/10.1126/science.abo7027

Vancouver

Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M et al. Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. SCIENCE. 2024 Apr 5;384(6691):eabo7027. https://doi.org/10.1126/science.abo7027

Bibtex

@article{3a7571c6dbaf4e7a9aa0bdab9947c2c8,
title = "Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages",
abstract = "Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of apoptotic neutrophils by macrophages triggered their tissue remodeling signature. Engulfment of apoptotic hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis of T cells had little effect on IL-4-induced gene expression. In a mouse model of parasite-induced pathology, the transfer of macrophages conditioned with IL-4 and apoptotic neutrophils promoted parasitic egg clearance. Knockout of phagocytic receptors required for the uptake of apoptotic neutrophils and partially T cells, but not hepatocytes, exacerbated helminth infection. These findings suggest that the identity of apoptotic cells may contribute to the development of distinct IL-4-driven immune programs in macrophages.",
keywords = "Animals, Mice, Apoptosis/immunology, Hepatocytes/immunology, Interleukin-4/genetics, Macrophages/immunology, Mice, Knockout, Neutrophils/immunology, Phagocytosis/immunology, Schistosomiasis mansoni/genetics, Disease Models, Animal",
author = "Imke Liebold and {Al Jawazneh}, Amirah and Christian Casar and Clarissa Lanzloth and Stephanie Leyk and Madeleine Hamley and Wong, {Milagros N} and Dominik Kylies and Gr{\"a}fe, {Stefanie K} and Ilka Edenhofer and Irene Aranda-Pardos and Marie Kriwet and Helmuth Haas and Jenny Krause and Alexandros Hadjilaou and Schromm, {Andra B} and Ulricke Richardt and Petra Eggert and Dennis Tappe and Weidemann, {S{\"o}ren A} and Sourav Ghosh and Krebs, {Christian F} and Noelia A-Gonzalez and Anna Worthmann and Lohse, {Ansgar W} and Samuel Huber and Rothlin, {Carla V} and Puelles, {Victor G} and Thomas Jacobs and Nicola Gagliani and Lidia Bosurgi",
year = "2024",
month = apr,
day = "5",
doi = "10.1126/science.abo7027",
language = "English",
volume = "384",
pages = "eabo7027",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6691",

}

RIS

TY - JOUR

T1 - Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

AU - Liebold, Imke

AU - Al Jawazneh, Amirah

AU - Casar, Christian

AU - Lanzloth, Clarissa

AU - Leyk, Stephanie

AU - Hamley, Madeleine

AU - Wong, Milagros N

AU - Kylies, Dominik

AU - Gräfe, Stefanie K

AU - Edenhofer, Ilka

AU - Aranda-Pardos, Irene

AU - Haas, Helmuth

AU - Krause, Jenny

AU - Hadjilaou, Alexandros

AU - Schromm, Andra B

AU - Richardt, Ulricke

AU - Eggert, Petra

AU - Tappe, Dennis

AU - Weidemann, Sören A

AU - Ghosh, Sourav

AU - Krebs, Christian F

AU - A-Gonzalez, Noelia

AU - Worthmann, Anna

AU - Lohse, Ansgar W

AU - Huber, Samuel

AU - Rothlin, Carla V

AU - Puelles, Victor G

AU - Jacobs, Thomas

AU - Gagliani, Nicola

AU - Bosurgi, Lidia

A2 - Kriwet, Marie

PY - 2024/4/5

Y1 - 2024/4/5

N2 - Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of apoptotic neutrophils by macrophages triggered their tissue remodeling signature. Engulfment of apoptotic hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis of T cells had little effect on IL-4-induced gene expression. In a mouse model of parasite-induced pathology, the transfer of macrophages conditioned with IL-4 and apoptotic neutrophils promoted parasitic egg clearance. Knockout of phagocytic receptors required for the uptake of apoptotic neutrophils and partially T cells, but not hepatocytes, exacerbated helminth infection. These findings suggest that the identity of apoptotic cells may contribute to the development of distinct IL-4-driven immune programs in macrophages.

AB - Macrophages are functionally heterogeneous cells essential for apoptotic cell clearance. Apoptotic cells are defined by homogeneous characteristics, ignoring their original cell lineage identity. We found that in an interleukin-4 (IL-4)-enriched environment, the sensing of apoptotic neutrophils by macrophages triggered their tissue remodeling signature. Engulfment of apoptotic hepatocytes promoted a tolerogenic phenotype, whereas phagocytosis of T cells had little effect on IL-4-induced gene expression. In a mouse model of parasite-induced pathology, the transfer of macrophages conditioned with IL-4 and apoptotic neutrophils promoted parasitic egg clearance. Knockout of phagocytic receptors required for the uptake of apoptotic neutrophils and partially T cells, but not hepatocytes, exacerbated helminth infection. These findings suggest that the identity of apoptotic cells may contribute to the development of distinct IL-4-driven immune programs in macrophages.

KW - Animals

KW - Mice

KW - Apoptosis/immunology

KW - Hepatocytes/immunology

KW - Interleukin-4/genetics

KW - Macrophages/immunology

KW - Mice, Knockout

KW - Neutrophils/immunology

KW - Phagocytosis/immunology

KW - Schistosomiasis mansoni/genetics

KW - Disease Models, Animal

U2 - 10.1126/science.abo7027

DO - 10.1126/science.abo7027

M3 - SCORING: Journal article

C2 - 38574142

VL - 384

SP - eabo7027

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6691

ER -