Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study
Standard
Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study. / Morgen, Katrin; Schneider, Michael; Frölich, Lutz; Tost, Heike; Plichta, Michael M; Kölsch, Heike; Rakebrandt, Fabian; Rienhoff, Otto; Jessen, Frank; Peters, Oliver; Jahn, Holger; Luckhaus, Christian; Hüll, Michael; Gertz, Hermann-Josef; Schröder, Johannes; Hampel, Harald; Teipel, Stefan J; Pantel, Johannes; Heuser, Isabella; Wiltfang, Jens; Rüther, Eckart; Kornhuber, Johannes; Maier, Wolfgang; Meyer-Lindenberg, Andreas.
In: ALZHEIMERS RES THER, Vol. 7, No. 1, 2015, p. 27.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study
AU - Morgen, Katrin
AU - Schneider, Michael
AU - Frölich, Lutz
AU - Tost, Heike
AU - Plichta, Michael M
AU - Kölsch, Heike
AU - Rakebrandt, Fabian
AU - Rienhoff, Otto
AU - Jessen, Frank
AU - Peters, Oliver
AU - Jahn, Holger
AU - Luckhaus, Christian
AU - Hüll, Michael
AU - Gertz, Hermann-Josef
AU - Schröder, Johannes
AU - Hampel, Harald
AU - Teipel, Stefan J
AU - Pantel, Johannes
AU - Heuser, Isabella
AU - Wiltfang, Jens
AU - Rüther, Eckart
AU - Kornhuber, Johannes
AU - Maier, Wolfgang
AU - Meyer-Lindenberg, Andreas
PY - 2015
Y1 - 2015
N2 - INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer's disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD.METHODS: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE ε4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network.RESULTS: WM hyperintensity volume was significantly greater in non-carriers of the APOE ε4 allele. Lesion distribution was similar among ε4 carriers and non-carriers. Only ε4 non-carriers showed a correlation between lesion volume and cognitive performance.CONCLUSION: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE ε4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE ε4-mediated risk.
AB - INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer's disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD.METHODS: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE ε4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network.RESULTS: WM hyperintensity volume was significantly greater in non-carriers of the APOE ε4 allele. Lesion distribution was similar among ε4 carriers and non-carriers. Only ε4 non-carriers showed a correlation between lesion volume and cognitive performance.CONCLUSION: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE ε4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE ε4-mediated risk.
U2 - 10.1186/s13195-015-0111-8
DO - 10.1186/s13195-015-0111-8
M3 - SCORING: Journal article
C2 - 25984242
VL - 7
SP - 27
JO - ALZHEIMERS RES THER
JF - ALZHEIMERS RES THER
SN - 1758-9193
IS - 1
ER -