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Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study

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Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study. / Morgen, Katrin; Schneider, Michael; Frölich, Lutz; Tost, Heike; Plichta, Michael M; Kölsch, Heike; Rakebrandt, Fabian; Rienhoff, Otto; Jessen, Frank; Peters, Oliver; Jahn, Holger; Luckhaus, Christian; Hüll, Michael; Gertz, Hermann-Josef; Schröder, Johannes; Hampel, Harald; Teipel, Stefan J; Pantel, Johannes; Heuser, Isabella; Wiltfang, Jens; Rüther, Eckart; Kornhuber, Johannes; Maier, Wolfgang; Meyer-Lindenberg, Andreas.

in: ALZHEIMERS RES THER, Jahrgang 7, Nr. 1, 2015, S. 27.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Morgen, K, Schneider, M, Frölich, L, Tost, H, Plichta, MM, Kölsch, H, Rakebrandt, F, Rienhoff, O, Jessen, F, Peters, O, Jahn, H, Luckhaus, C, Hüll, M, Gertz, H-J, Schröder, J, Hampel, H, Teipel, SJ, Pantel, J, Heuser, I, Wiltfang, J, Rüther, E, Kornhuber, J, Maier, W & Meyer-Lindenberg, A 2015, 'Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study', ALZHEIMERS RES THER, Jg. 7, Nr. 1, S. 27. https://doi.org/10.1186/s13195-015-0111-8

APA

Morgen, K., Schneider, M., Frölich, L., Tost, H., Plichta, M. M., Kölsch, H., Rakebrandt, F., Rienhoff, O., Jessen, F., Peters, O., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H-J., Schröder, J., Hampel, H., Teipel, S. J., Pantel, J., Heuser, I., ... Meyer-Lindenberg, A. (2015). Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study. ALZHEIMERS RES THER, 7(1), 27. https://doi.org/10.1186/s13195-015-0111-8

Vancouver

Morgen K, Schneider M, Frölich L, Tost H, Plichta MM, Kölsch H et al. Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study. ALZHEIMERS RES THER. 2015;7(1):27. https://doi.org/10.1186/s13195-015-0111-8

Bibtex

@article{4c1df14b429a41ad856e1ff35bdb385c,
title = "Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study",
abstract = "INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer's disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD.METHODS: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE ε4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network.RESULTS: WM hyperintensity volume was significantly greater in non-carriers of the APOE ε4 allele. Lesion distribution was similar among ε4 carriers and non-carriers. Only ε4 non-carriers showed a correlation between lesion volume and cognitive performance.CONCLUSION: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE ε4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE ε4-mediated risk.",
author = "Katrin Morgen and Michael Schneider and Lutz Fr{\"o}lich and Heike Tost and Plichta, {Michael M} and Heike K{\"o}lsch and Fabian Rakebrandt and Otto Rienhoff and Frank Jessen and Oliver Peters and Holger Jahn and Christian Luckhaus and Michael H{\"u}ll and Hermann-Josef Gertz and Johannes Schr{\"o}der and Harald Hampel and Teipel, {Stefan J} and Johannes Pantel and Isabella Heuser and Jens Wiltfang and Eckart R{\"u}ther and Johannes Kornhuber and Wolfgang Maier and Andreas Meyer-Lindenberg",
year = "2015",
doi = "10.1186/s13195-015-0111-8",
language = "English",
volume = "7",
pages = "27",
journal = "ALZHEIMERS RES THER",
issn = "1758-9193",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study

AU - Morgen, Katrin

AU - Schneider, Michael

AU - Frölich, Lutz

AU - Tost, Heike

AU - Plichta, Michael M

AU - Kölsch, Heike

AU - Rakebrandt, Fabian

AU - Rienhoff, Otto

AU - Jessen, Frank

AU - Peters, Oliver

AU - Jahn, Holger

AU - Luckhaus, Christian

AU - Hüll, Michael

AU - Gertz, Hermann-Josef

AU - Schröder, Johannes

AU - Hampel, Harald

AU - Teipel, Stefan J

AU - Pantel, Johannes

AU - Heuser, Isabella

AU - Wiltfang, Jens

AU - Rüther, Eckart

AU - Kornhuber, Johannes

AU - Maier, Wolfgang

AU - Meyer-Lindenberg, Andreas

PY - 2015

Y1 - 2015

N2 - INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer's disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD.METHODS: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE ε4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network.RESULTS: WM hyperintensity volume was significantly greater in non-carriers of the APOE ε4 allele. Lesion distribution was similar among ε4 carriers and non-carriers. Only ε4 non-carriers showed a correlation between lesion volume and cognitive performance.CONCLUSION: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE ε4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE ε4-mediated risk.

AB - INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer's disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects on the extent and cognitive impact of WM hyperintensities in patients with AD.METHODS: WM hyperintensity volume on fluid-attenuated inversion recovery images of 201 patients with AD (128 carriers and 73 non-carriers of the APOE ε4 risk allele) was determined globally as well as regionally with voxel-based lesion mapping. Clinical, neuropsychological and MRI data were collected from prospective multicenter trials conducted by the German Dementia Competence Network.RESULTS: WM hyperintensity volume was significantly greater in non-carriers of the APOE ε4 allele. Lesion distribution was similar among ε4 carriers and non-carriers. Only ε4 non-carriers showed a correlation between lesion volume and cognitive performance.CONCLUSION: The current findings indicate an increased prevalence of WM hyperintensities in non-carriers compared with carriers of the APOE ε4 allele among patients with AD. This is consistent with a possibly more pronounced contribution of heterogeneous vascular risk factors to WM damage and cognitive impairment in patients with AD without APOE ε4-mediated risk.

U2 - 10.1186/s13195-015-0111-8

DO - 10.1186/s13195-015-0111-8

M3 - SCORING: Journal article

C2 - 25984242

VL - 7

SP - 27

JO - ALZHEIMERS RES THER

JF - ALZHEIMERS RES THER

SN - 1758-9193

IS - 1

ER -