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Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome

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Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome. / Dammermann, Werner; Mihajlov, Valentin; Middendorf, Barbara; Mellmann, Alexander; Karch, Helge; Lüth, Stefan; Ullrich, Sebastian.

In: J GASTROEN HEPATOL, Vol. 33, No. 7, 07.2018, p. 1353-1356.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dammermann, W, Mihajlov, V, Middendorf, B, Mellmann, A, Karch, H, Lüth, S & Ullrich, S 2018, 'Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome', J GASTROEN HEPATOL, vol. 33, no. 7, pp. 1353-1356. https://doi.org/10.1111/jgh.14082

APA

Dammermann, W., Mihajlov, V., Middendorf, B., Mellmann, A., Karch, H., Lüth, S., & Ullrich, S. (2018). Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome. J GASTROEN HEPATOL, 33(7), 1353-1356. https://doi.org/10.1111/jgh.14082

Vancouver

Dammermann W, Mihajlov V, Middendorf B, Mellmann A, Karch H, Lüth S et al. Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome. J GASTROEN HEPATOL. 2018 Jul;33(7):1353-1356. https://doi.org/10.1111/jgh.14082

Bibtex

@article{3aba8ff456ea4808bad4038dcf9654c1,
title = "Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome",
abstract = "BACKGROUND AND AIM: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.METHODS: Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non-HUS: n = 9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.RESULTS: Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.CONCLUSIONS: Anti-Stx2 antibodies seem to accompany or even precede HUS development.",
keywords = "Journal Article, Immunoglobulin G/blood, Immunoglobulin M/blood, Predictive Value of Tests, Escherichia coli O104/immunology, Shiga Toxin 2/immunology, Antibodies, Bacterial/blood, Humans, Hemolytic-Uremic Syndrome/diagnosis, Escherichia coli Infections/complications, Fever/etiology, Plasmapheresis, Anti-Bacterial Agents, Acute-Phase Reaction, Biomarkers/blood, Retrospective Studies, Superinfection, Nervous System Diseases",
author = "Werner Dammermann and Valentin Mihajlov and Barbara Middendorf and Alexander Mellmann and Helge Karch and Stefan L{\"u}th and Sebastian Ullrich",
note = "{\textcopyright} 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.",
year = "2018",
month = jul,
doi = "10.1111/jgh.14082",
language = "English",
volume = "33",
pages = "1353--1356",
journal = "J GASTROEN HEPATOL",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome

AU - Dammermann, Werner

AU - Mihajlov, Valentin

AU - Middendorf, Barbara

AU - Mellmann, Alexander

AU - Karch, Helge

AU - Lüth, Stefan

AU - Ullrich, Sebastian

N1 - © 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

PY - 2018/7

Y1 - 2018/7

N2 - BACKGROUND AND AIM: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.METHODS: Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non-HUS: n = 9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.RESULTS: Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.CONCLUSIONS: Anti-Stx2 antibodies seem to accompany or even precede HUS development.

AB - BACKGROUND AND AIM: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.METHODS: Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non-HUS: n = 9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.RESULTS: Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.CONCLUSIONS: Anti-Stx2 antibodies seem to accompany or even precede HUS development.

KW - Journal Article

KW - Immunoglobulin G/blood

KW - Immunoglobulin M/blood

KW - Predictive Value of Tests

KW - Escherichia coli O104/immunology

KW - Shiga Toxin 2/immunology

KW - Antibodies, Bacterial/blood

KW - Humans

KW - Hemolytic-Uremic Syndrome/diagnosis

KW - Escherichia coli Infections/complications

KW - Fever/etiology

KW - Plasmapheresis

KW - Anti-Bacterial Agents

KW - Acute-Phase Reaction

KW - Biomarkers/blood

KW - Retrospective Studies

KW - Superinfection

KW - Nervous System Diseases

U2 - 10.1111/jgh.14082

DO - 10.1111/jgh.14082

M3 - SCORING: Journal article

C2 - 29280264

VL - 33

SP - 1353

EP - 1356

JO - J GASTROEN HEPATOL

JF - J GASTROEN HEPATOL

SN - 0815-9319

IS - 7

ER -