Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome
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Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome. / Dammermann, Werner; Mihajlov, Valentin; Middendorf, Barbara; Mellmann, Alexander; Karch, Helge; Lüth, Stefan; Ullrich, Sebastian.
in: J GASTROEN HEPATOL, Jahrgang 33, Nr. 7, 07.2018, S. 1353-1356.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome
AU - Dammermann, Werner
AU - Mihajlov, Valentin
AU - Middendorf, Barbara
AU - Mellmann, Alexander
AU - Karch, Helge
AU - Lüth, Stefan
AU - Ullrich, Sebastian
N1 - © 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
PY - 2018/7
Y1 - 2018/7
N2 - BACKGROUND AND AIM: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.METHODS: Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non-HUS: n = 9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.RESULTS: Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.CONCLUSIONS: Anti-Stx2 antibodies seem to accompany or even precede HUS development.
AB - BACKGROUND AND AIM: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.METHODS: Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non-HUS: n = 9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.RESULTS: Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.CONCLUSIONS: Anti-Stx2 antibodies seem to accompany or even precede HUS development.
KW - Journal Article
KW - Immunoglobulin G/blood
KW - Immunoglobulin M/blood
KW - Predictive Value of Tests
KW - Escherichia coli O104/immunology
KW - Shiga Toxin 2/immunology
KW - Antibodies, Bacterial/blood
KW - Humans
KW - Hemolytic-Uremic Syndrome/diagnosis
KW - Escherichia coli Infections/complications
KW - Fever/etiology
KW - Plasmapheresis
KW - Anti-Bacterial Agents
KW - Acute-Phase Reaction
KW - Biomarkers/blood
KW - Retrospective Studies
KW - Superinfection
KW - Nervous System Diseases
U2 - 10.1111/jgh.14082
DO - 10.1111/jgh.14082
M3 - SCORING: Journal article
C2 - 29280264
VL - 33
SP - 1353
EP - 1356
JO - J GASTROEN HEPATOL
JF - J GASTROEN HEPATOL
SN - 0815-9319
IS - 7
ER -