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Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors.

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Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors. / Guha, C; Guha, U; Tribius, Silke; Alfieri, A; Casper, D; Chakravarty, P; Mellado, W; Pandita, T K; Vikram, B.

In: GENE THER, Vol. 7, No. 10, 10, 2000, p. 852-858.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Guha, C, Guha, U, Tribius, S, Alfieri, A, Casper, D, Chakravarty, P, Mellado, W, Pandita, TK & Vikram, B 2000, 'Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors.', GENE THER, vol. 7, no. 10, 10, pp. 852-858. <http://www.ncbi.nlm.nih.gov/pubmed/10845723?dopt=Citation>

APA

Guha, C., Guha, U., Tribius, S., Alfieri, A., Casper, D., Chakravarty, P., Mellado, W., Pandita, T. K., & Vikram, B. (2000). Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors. GENE THER, 7(10), 852-858. [10]. http://www.ncbi.nlm.nih.gov/pubmed/10845723?dopt=Citation

Vancouver

Guha C, Guha U, Tribius S, Alfieri A, Casper D, Chakravarty P et al. Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors. GENE THER. 2000;7(10):852-858. 10.

Bibtex

@article{4799b6577c934ec8b89417f9ca62ca8f,
title = "Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors.",
abstract = "Atm, the gene mutated in ataxia-telangiectasia (AT) patients, is an essential component of the signal transduction pathway that responds to DNA damage due to ionizing radiation (IR). We attenuated ATM protein expression in human glioblastoma cells by expressing antisense RNA to a functional domain of the atm gene. While ATM expression decreased, constitutive expression of p53 and p21 increased. Irradiated ATM-attenuated cells failed to induce p53, demonstrated radioresistant DNA synthesis, and increased radiosensitivity. Antisense-ATM gene therapy in conjunction with radiation therapy may provide a novel strategy for the treatment of cancer.",
author = "C Guha and U Guha and Silke Tribius and A Alfieri and D Casper and P Chakravarty and W Mellado and Pandita, {T K} and B Vikram",
year = "2000",
language = "Deutsch",
volume = "7",
pages = "852--858",
journal = "GENE THER",
issn = "0969-7128",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors.

AU - Guha, C

AU - Guha, U

AU - Tribius, Silke

AU - Alfieri, A

AU - Casper, D

AU - Chakravarty, P

AU - Mellado, W

AU - Pandita, T K

AU - Vikram, B

PY - 2000

Y1 - 2000

N2 - Atm, the gene mutated in ataxia-telangiectasia (AT) patients, is an essential component of the signal transduction pathway that responds to DNA damage due to ionizing radiation (IR). We attenuated ATM protein expression in human glioblastoma cells by expressing antisense RNA to a functional domain of the atm gene. While ATM expression decreased, constitutive expression of p53 and p21 increased. Irradiated ATM-attenuated cells failed to induce p53, demonstrated radioresistant DNA synthesis, and increased radiosensitivity. Antisense-ATM gene therapy in conjunction with radiation therapy may provide a novel strategy for the treatment of cancer.

AB - Atm, the gene mutated in ataxia-telangiectasia (AT) patients, is an essential component of the signal transduction pathway that responds to DNA damage due to ionizing radiation (IR). We attenuated ATM protein expression in human glioblastoma cells by expressing antisense RNA to a functional domain of the atm gene. While ATM expression decreased, constitutive expression of p53 and p21 increased. Irradiated ATM-attenuated cells failed to induce p53, demonstrated radioresistant DNA synthesis, and increased radiosensitivity. Antisense-ATM gene therapy in conjunction with radiation therapy may provide a novel strategy for the treatment of cancer.

M3 - SCORING: Zeitschriftenaufsatz

VL - 7

SP - 852

EP - 858

JO - GENE THER

JF - GENE THER

SN - 0969-7128

IS - 10

M1 - 10

ER -