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Anticholinergic drug use and risk for dementia: target for dementia prevention.

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Anticholinergic drug use and risk for dementia: target for dementia prevention. / Jessen, Frank; Kaduszkiewicz, Hanna; Daerr, Moritz; Bickel, Horst; Pentzek, Michael; Riedel-Heller, Steffi; Wagner, Michael; Weyerer, Siegfried; Wiese, Birgitt; Bussche van den, Hendrik; Broich, Karl; Maier, Wolfgang.

In: EUR ARCH PSY CLIN N, Vol. 260, No. 2, 2, 2010, p. 111-115.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jessen, F, Kaduszkiewicz, H, Daerr, M, Bickel, H, Pentzek, M, Riedel-Heller, S, Wagner, M, Weyerer, S, Wiese, B, Bussche van den, H, Broich, K & Maier, W 2010, 'Anticholinergic drug use and risk for dementia: target for dementia prevention.', EUR ARCH PSY CLIN N, vol. 260, no. 2, 2, pp. 111-115. <http://www.ncbi.nlm.nih.gov/pubmed/20960005?dopt=Citation>

APA

Jessen, F., Kaduszkiewicz, H., Daerr, M., Bickel, H., Pentzek, M., Riedel-Heller, S., Wagner, M., Weyerer, S., Wiese, B., Bussche van den, H., Broich, K., & Maier, W. (2010). Anticholinergic drug use and risk for dementia: target for dementia prevention. EUR ARCH PSY CLIN N, 260(2), 111-115. [2]. http://www.ncbi.nlm.nih.gov/pubmed/20960005?dopt=Citation

Vancouver

Jessen F, Kaduszkiewicz H, Daerr M, Bickel H, Pentzek M, Riedel-Heller S et al. Anticholinergic drug use and risk for dementia: target for dementia prevention. EUR ARCH PSY CLIN N. 2010;260(2):111-115. 2.

Bibtex

@article{2600a26179324fc38db17fd45bbf1a05,
title = "Anticholinergic drug use and risk for dementia: target for dementia prevention.",
abstract = "An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition.",
author = "Frank Jessen and Hanna Kaduszkiewicz and Moritz Daerr and Horst Bickel and Michael Pentzek and Steffi Riedel-Heller and Michael Wagner and Siegfried Weyerer and Birgitt Wiese and {Bussche van den}, Hendrik and Karl Broich and Wolfgang Maier",
year = "2010",
language = "Deutsch",
volume = "260",
pages = "111--115",
journal = "EUR ARCH PSY CLIN N",
issn = "0940-1334",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - Anticholinergic drug use and risk for dementia: target for dementia prevention.

AU - Jessen, Frank

AU - Kaduszkiewicz, Hanna

AU - Daerr, Moritz

AU - Bickel, Horst

AU - Pentzek, Michael

AU - Riedel-Heller, Steffi

AU - Wagner, Michael

AU - Weyerer, Siegfried

AU - Wiese, Birgitt

AU - Bussche van den, Hendrik

AU - Broich, Karl

AU - Maier, Wolfgang

PY - 2010

Y1 - 2010

N2 - An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition.

AB - An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition.

M3 - SCORING: Zeitschriftenaufsatz

VL - 260

SP - 111

EP - 115

JO - EUR ARCH PSY CLIN N

JF - EUR ARCH PSY CLIN N

SN - 0940-1334

IS - 2

M1 - 2

ER -