Anticholinergic drug use and risk for dementia: target for dementia prevention.
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Anticholinergic drug use and risk for dementia: target for dementia prevention. / Jessen, Frank; Kaduszkiewicz, Hanna; Daerr, Moritz; Bickel, Horst; Pentzek, Michael; Riedel-Heller, Steffi; Wagner, Michael; Weyerer, Siegfried; Wiese, Birgitt; Bussche van den, Hendrik; Broich, Karl; Maier, Wolfgang.
in: EUR ARCH PSY CLIN N, Jahrgang 260, Nr. 2, 2, 2010, S. 111-115.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Anticholinergic drug use and risk for dementia: target for dementia prevention.
AU - Jessen, Frank
AU - Kaduszkiewicz, Hanna
AU - Daerr, Moritz
AU - Bickel, Horst
AU - Pentzek, Michael
AU - Riedel-Heller, Steffi
AU - Wagner, Michael
AU - Weyerer, Siegfried
AU - Wiese, Birgitt
AU - Bussche van den, Hendrik
AU - Broich, Karl
AU - Maier, Wolfgang
PY - 2010
Y1 - 2010
N2 - An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition.
AB - An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition.
M3 - SCORING: Zeitschriftenaufsatz
VL - 260
SP - 111
EP - 115
JO - EUR ARCH PSY CLIN N
JF - EUR ARCH PSY CLIN N
SN - 0940-1334
IS - 2
M1 - 2
ER -