Antibody prevalence to the 2009 pandemic influenza A (H1N1) virus in Germany: geographically variable immunity in winter 2010/2011
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Antibody prevalence to the 2009 pandemic influenza A (H1N1) virus in Germany: geographically variable immunity in winter 2010/2011. / Hackenberg, Anne; Arman-Kalcek, Gökhan; Hiller, Jens; Gabriel, Gülsah.
In: Medical microbiology and immunology, Vol. 202, No. 1, 01.02.2013, p. 87-94.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Antibody prevalence to the 2009 pandemic influenza A (H1N1) virus in Germany: geographically variable immunity in winter 2010/2011
AU - Hackenberg, Anne
AU - Arman-Kalcek, Gökhan
AU - Hiller, Jens
AU - Gabriel, Gülsah
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Location- and age-specific prevalence of antibodies against 2009 pandemic influenza A (H1N1) virus were determined in sera of blood donors collected during winter 2010/2011 in Germany. Prevalence of antibodies at protective titres (HI ≥1:40) varied significantly between cities (24.13-83.67 %) throughout all age groups. However, high level antibodies (HI >1:80) were most prevalent among young individuals (18-29 and 30-39 years). Overall, this study demonstrates that older people (50-59 and 60-70 years) are no longer more likely to present protective antibody titres against 2009 pandemic influenza A (H1N1) virus than younger individuals. Furthermore, our data show a highly variable immunity among the German population in different major cities almost 2 years after the detection of first cases in Germany.
AB - Location- and age-specific prevalence of antibodies against 2009 pandemic influenza A (H1N1) virus were determined in sera of blood donors collected during winter 2010/2011 in Germany. Prevalence of antibodies at protective titres (HI ≥1:40) varied significantly between cities (24.13-83.67 %) throughout all age groups. However, high level antibodies (HI >1:80) were most prevalent among young individuals (18-29 and 30-39 years). Overall, this study demonstrates that older people (50-59 and 60-70 years) are no longer more likely to present protective antibody titres against 2009 pandemic influenza A (H1N1) virus than younger individuals. Furthermore, our data show a highly variable immunity among the German population in different major cities almost 2 years after the detection of first cases in Germany.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Aged
KW - Antibodies, Viral
KW - Female
KW - Germany
KW - Humans
KW - Influenza A Virus, H1N1 Subtype
KW - Influenza, Human
KW - Male
KW - Middle Aged
KW - Seroepidemiologic Studies
KW - Young Adult
U2 - 10.1007/s00430-012-0251-4
DO - 10.1007/s00430-012-0251-4
M3 - SCORING: Journal article
C2 - 22684725
VL - 202
SP - 87
EP - 94
JO - MED MICROBIOL IMMUN
JF - MED MICROBIOL IMMUN
SN - 0300-8584
IS - 1
ER -