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Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris

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Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris. / Kähler, Jan; Gerth, Sabine; Schäfer, Peter; Boersma, Eric; Köster, Ralf; Terres, Wolfram; Simoons, Maarten L.; Berger, Joachim; Meinertz, Thomas; Hamm, Christian W.

In: AM J CARDIOL, Vol. 87, No. 10, 15.05.2001, p. 1150-1153.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kähler, J, Gerth, S, Schäfer, P, Boersma, E, Köster, R, Terres, W, Simoons, ML, Berger, J, Meinertz, T & Hamm, CW 2001, 'Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris', AM J CARDIOL, vol. 87, no. 10, pp. 1150-1153. https://doi.org/10.1016/S0002-9149(01)01484-9

APA

Kähler, J., Gerth, S., Schäfer, P., Boersma, E., Köster, R., Terres, W., Simoons, M. L., Berger, J., Meinertz, T., & Hamm, C. W. (2001). Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris. AM J CARDIOL, 87(10), 1150-1153. https://doi.org/10.1016/S0002-9149(01)01484-9

Vancouver

Kähler J, Gerth S, Schäfer P, Boersma E, Köster R, Terres W et al. Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris. AM J CARDIOL. 2001 May 15;87(10):1150-1153. https://doi.org/10.1016/S0002-9149(01)01484-9

Bibtex

@article{d1722c1cb7d844a6b17ce8d55fe238cd,
title = "Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris",
abstract = "Patients with coronary artery disease frequently have elevated antibody titers against Chlamydia pneumoniae, but whether antichlamydial antibody titers are correlated with prognosis in unstable angina remains unclear. We therefore investigated the sera of 1,096 patients with unstable angina regarding immunoglobulin (Ig) IgG, IgA, and IgM antibody titers against chlamydial lipopolysaccharides (LPS) and the concentrations of C-reactive protein (CRP) and troponin T (TnT). Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001). Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001). Patients who subsequently died had significantly lower IgM titers at enrollment than patients without events (p = 0.016). IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT. In this large-scale study of patients with unstable angina, we frequently found elevated antichlamydial antibody titers. Patients with low IgM anti-LPS titers were at risk for subsequent death. However, there was no correlation between antichlamydial antibody titers and CRP or TnT.",
author = "Jan K{\"a}hler and Sabine Gerth and Peter Sch{\"a}fer and Eric Boersma and Ralf K{\"o}ster and Wolfram Terres and Simoons, {Maarten L.} and Joachim Berger and Thomas Meinertz and Hamm, {Christian W.}",
year = "2001",
month = may,
day = "15",
doi = "10.1016/S0002-9149(01)01484-9",
language = "English",
volume = "87",
pages = "1150--1153",
journal = "AM J CARDIOL",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris

AU - Kähler, Jan

AU - Gerth, Sabine

AU - Schäfer, Peter

AU - Boersma, Eric

AU - Köster, Ralf

AU - Terres, Wolfram

AU - Simoons, Maarten L.

AU - Berger, Joachim

AU - Meinertz, Thomas

AU - Hamm, Christian W.

PY - 2001/5/15

Y1 - 2001/5/15

N2 - Patients with coronary artery disease frequently have elevated antibody titers against Chlamydia pneumoniae, but whether antichlamydial antibody titers are correlated with prognosis in unstable angina remains unclear. We therefore investigated the sera of 1,096 patients with unstable angina regarding immunoglobulin (Ig) IgG, IgA, and IgM antibody titers against chlamydial lipopolysaccharides (LPS) and the concentrations of C-reactive protein (CRP) and troponin T (TnT). Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001). Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001). Patients who subsequently died had significantly lower IgM titers at enrollment than patients without events (p = 0.016). IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT. In this large-scale study of patients with unstable angina, we frequently found elevated antichlamydial antibody titers. Patients with low IgM anti-LPS titers were at risk for subsequent death. However, there was no correlation between antichlamydial antibody titers and CRP or TnT.

AB - Patients with coronary artery disease frequently have elevated antibody titers against Chlamydia pneumoniae, but whether antichlamydial antibody titers are correlated with prognosis in unstable angina remains unclear. We therefore investigated the sera of 1,096 patients with unstable angina regarding immunoglobulin (Ig) IgG, IgA, and IgM antibody titers against chlamydial lipopolysaccharides (LPS) and the concentrations of C-reactive protein (CRP) and troponin T (TnT). Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001). Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001). Patients who subsequently died had significantly lower IgM titers at enrollment than patients without events (p = 0.016). IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT. In this large-scale study of patients with unstable angina, we frequently found elevated antichlamydial antibody titers. Patients with low IgM anti-LPS titers were at risk for subsequent death. However, there was no correlation between antichlamydial antibody titers and CRP or TnT.

UR - http://www.scopus.com/inward/record.url?scp=17144438831&partnerID=8YFLogxK

U2 - 10.1016/S0002-9149(01)01484-9

DO - 10.1016/S0002-9149(01)01484-9

M3 - SCORING: Journal article

C2 - 11356388

AN - SCOPUS:17144438831

VL - 87

SP - 1150

EP - 1153

JO - AM J CARDIOL

JF - AM J CARDIOL

SN - 0002-9149

IS - 10

ER -