Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris
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Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris. / Kähler, Jan; Gerth, Sabine; Schäfer, Peter; Boersma, Eric; Köster, Ralf; Terres, Wolfram; Simoons, Maarten L.; Berger, Joachim; Meinertz, Thomas; Hamm, Christian W.
in: AM J CARDIOL, Jahrgang 87, Nr. 10, 15.05.2001, S. 1150-1153.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris
AU - Kähler, Jan
AU - Gerth, Sabine
AU - Schäfer, Peter
AU - Boersma, Eric
AU - Köster, Ralf
AU - Terres, Wolfram
AU - Simoons, Maarten L.
AU - Berger, Joachim
AU - Meinertz, Thomas
AU - Hamm, Christian W.
PY - 2001/5/15
Y1 - 2001/5/15
N2 - Patients with coronary artery disease frequently have elevated antibody titers against Chlamydia pneumoniae, but whether antichlamydial antibody titers are correlated with prognosis in unstable angina remains unclear. We therefore investigated the sera of 1,096 patients with unstable angina regarding immunoglobulin (Ig) IgG, IgA, and IgM antibody titers against chlamydial lipopolysaccharides (LPS) and the concentrations of C-reactive protein (CRP) and troponin T (TnT). Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001). Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001). Patients who subsequently died had significantly lower IgM titers at enrollment than patients without events (p = 0.016). IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT. In this large-scale study of patients with unstable angina, we frequently found elevated antichlamydial antibody titers. Patients with low IgM anti-LPS titers were at risk for subsequent death. However, there was no correlation between antichlamydial antibody titers and CRP or TnT.
AB - Patients with coronary artery disease frequently have elevated antibody titers against Chlamydia pneumoniae, but whether antichlamydial antibody titers are correlated with prognosis in unstable angina remains unclear. We therefore investigated the sera of 1,096 patients with unstable angina regarding immunoglobulin (Ig) IgG, IgA, and IgM antibody titers against chlamydial lipopolysaccharides (LPS) and the concentrations of C-reactive protein (CRP) and troponin T (TnT). Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001). Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001). Patients who subsequently died had significantly lower IgM titers at enrollment than patients without events (p = 0.016). IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT. In this large-scale study of patients with unstable angina, we frequently found elevated antichlamydial antibody titers. Patients with low IgM anti-LPS titers were at risk for subsequent death. However, there was no correlation between antichlamydial antibody titers and CRP or TnT.
UR - http://www.scopus.com/inward/record.url?scp=17144438831&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(01)01484-9
DO - 10.1016/S0002-9149(01)01484-9
M3 - SCORING: Journal article
C2 - 11356388
AN - SCOPUS:17144438831
VL - 87
SP - 1150
EP - 1153
JO - AM J CARDIOL
JF - AM J CARDIOL
SN - 0002-9149
IS - 10
ER -