Analysis of pralidoxime in serum, brain and CSF of rats.
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Analysis of pralidoxime in serum, brain and CSF of rats. / Kalász, Huba; Szöko, Eva; Tábi, Tamás; Petroianu, Georg A; Lorke, Dietrich; Omar, Abdulrab; Alafifi, Salem; Jasem, Almerri; Tekes, Kornélia.
In: MED CHEM, Vol. 5, No. 3, 3, 2009, p. 237-241.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Analysis of pralidoxime in serum, brain and CSF of rats.
AU - Kalász, Huba
AU - Szöko, Eva
AU - Tábi, Tamás
AU - Petroianu, Georg A
AU - Lorke, Dietrich
AU - Omar, Abdulrab
AU - Alafifi, Salem
AU - Jasem, Almerri
AU - Tekes, Kornélia
PY - 2009
Y1 - 2009
N2 - After administration of various amounts of pralidoxime to rats, the levels in serum, brain and cerebrospinal fluid (CSF) were measured using capillary zone electrophoresis (CZE). The calibration curves were established using spiked samples. The calibration covers the ranges from 0.3 - 200 microg/mL, 0.3 - 7 microg/mL and 0.1 - 7 microg/mL for serum, brain and CSF, respectively. The CZE measurement opens the way to the fast and reliable determination of pyridinium aldoxime concentrations in serum, cerebrospinal fluid and brain, thereby monitoring blood-brain and blood-CSF penetration of pyridinium aldoxime-type antidotes clinically used in organophosphate poisoning.
AB - After administration of various amounts of pralidoxime to rats, the levels in serum, brain and cerebrospinal fluid (CSF) were measured using capillary zone electrophoresis (CZE). The calibration curves were established using spiked samples. The calibration covers the ranges from 0.3 - 200 microg/mL, 0.3 - 7 microg/mL and 0.1 - 7 microg/mL for serum, brain and CSF, respectively. The CZE measurement opens the way to the fast and reliable determination of pyridinium aldoxime concentrations in serum, cerebrospinal fluid and brain, thereby monitoring blood-brain and blood-CSF penetration of pyridinium aldoxime-type antidotes clinically used in organophosphate poisoning.
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 237
EP - 241
JO - MED CHEM
JF - MED CHEM
SN - 1573-4064
IS - 3
M1 - 3
ER -