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An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury

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An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury. / Middleton, Devon M; Mohamed, Feroze B; Barakat, Nadia; Hunter, Louis N; Shellikeri, Sphoorti; Finsterbusch, Jürgen; Faro, Scott H; Shah, Pallav; Samdani, Amer F; Mulcahey, M J.

In: MAGN RESON IMAGING, Vol. 32, No. 5, 01.06.2014, p. 433-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Middleton, DM, Mohamed, FB, Barakat, N, Hunter, LN, Shellikeri, S, Finsterbusch, J, Faro, SH, Shah, P, Samdani, AF & Mulcahey, MJ 2014, 'An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury', MAGN RESON IMAGING, vol. 32, no. 5, pp. 433-9. https://doi.org/10.1016/j.mri.2014.01.020

APA

Middleton, D. M., Mohamed, F. B., Barakat, N., Hunter, L. N., Shellikeri, S., Finsterbusch, J., Faro, S. H., Shah, P., Samdani, A. F., & Mulcahey, M. J. (2014). An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury. MAGN RESON IMAGING, 32(5), 433-9. https://doi.org/10.1016/j.mri.2014.01.020

Vancouver

Middleton DM, Mohamed FB, Barakat N, Hunter LN, Shellikeri S, Finsterbusch J et al. An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury. MAGN RESON IMAGING. 2014 Jun 1;32(5):433-9. https://doi.org/10.1016/j.mri.2014.01.020

Bibtex

@article{e5474a0e8e3a4da1be24ce0f5c8e9257,
title = "An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury",
abstract = "Patient and physiological motion can cause artifacts in DTI of the spinal cord which can impact image quality and diffusion indices. The purpose of this investigation was to determine a reliable motion correction method for pediatric spinal cord DTI and show effects of motion correction on DTI parameters in healthy subjects and patients with spinal cord injury. Ten healthy subjects and ten subjects with spinal cord injury were scanned using a 3T scanner. Images were acquired with an inner field-of-view DTI sequence covering cervical spine levels C1 to C7. Images were corrected for motion using two types of transformation (rigid and affine) and three cost functions. Corrected images and transformations were examined qualitatively and quantitatively using in-house developed code. Fractional anisotropy (FA) and mean diffusivity (MD) indices were calculated and tested for statistical significance pre- and post- motion correction. Images corrected using rigid methods showed improvements in image quality, while affine methods frequently showed residual distortions in corrected images. Blinded evaluation of pre and post correction images showed significant improvement in cord homogeneity and edge conspicuity in corrected images (p<0.0001). The average FA changes were statistically significant (p<0.0001) in the spinal cord injury group, while healthy subjects showed less FA change and were not significant. In both healthy subjects and subjects with spinal cord injury, quantitative and qualitative analysis showed the rigid scaled-least-squares registration technique to be the most reliable and effective in improving image quality.",
keywords = "Adolescent, Algorithms, Artifacts, Child, Diffusion Tensor Imaging, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Motion, Pattern Recognition, Automated, Sensitivity and Specificity, Spinal Cord, Spinal Cord Injuries, Subtraction Technique, Young Adult",
author = "Middleton, {Devon M} and Mohamed, {Feroze B} and Nadia Barakat and Hunter, {Louis N} and Sphoorti Shellikeri and J{\"u}rgen Finsterbusch and Faro, {Scott H} and Pallav Shah and Samdani, {Amer F} and Mulcahey, {M J}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = jun,
day = "1",
doi = "10.1016/j.mri.2014.01.020",
language = "English",
volume = "32",
pages = "433--9",
journal = "MAGN RESON IMAGING",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury

AU - Middleton, Devon M

AU - Mohamed, Feroze B

AU - Barakat, Nadia

AU - Hunter, Louis N

AU - Shellikeri, Sphoorti

AU - Finsterbusch, Jürgen

AU - Faro, Scott H

AU - Shah, Pallav

AU - Samdani, Amer F

AU - Mulcahey, M J

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Patient and physiological motion can cause artifacts in DTI of the spinal cord which can impact image quality and diffusion indices. The purpose of this investigation was to determine a reliable motion correction method for pediatric spinal cord DTI and show effects of motion correction on DTI parameters in healthy subjects and patients with spinal cord injury. Ten healthy subjects and ten subjects with spinal cord injury were scanned using a 3T scanner. Images were acquired with an inner field-of-view DTI sequence covering cervical spine levels C1 to C7. Images were corrected for motion using two types of transformation (rigid and affine) and three cost functions. Corrected images and transformations were examined qualitatively and quantitatively using in-house developed code. Fractional anisotropy (FA) and mean diffusivity (MD) indices were calculated and tested for statistical significance pre- and post- motion correction. Images corrected using rigid methods showed improvements in image quality, while affine methods frequently showed residual distortions in corrected images. Blinded evaluation of pre and post correction images showed significant improvement in cord homogeneity and edge conspicuity in corrected images (p<0.0001). The average FA changes were statistically significant (p<0.0001) in the spinal cord injury group, while healthy subjects showed less FA change and were not significant. In both healthy subjects and subjects with spinal cord injury, quantitative and qualitative analysis showed the rigid scaled-least-squares registration technique to be the most reliable and effective in improving image quality.

AB - Patient and physiological motion can cause artifacts in DTI of the spinal cord which can impact image quality and diffusion indices. The purpose of this investigation was to determine a reliable motion correction method for pediatric spinal cord DTI and show effects of motion correction on DTI parameters in healthy subjects and patients with spinal cord injury. Ten healthy subjects and ten subjects with spinal cord injury were scanned using a 3T scanner. Images were acquired with an inner field-of-view DTI sequence covering cervical spine levels C1 to C7. Images were corrected for motion using two types of transformation (rigid and affine) and three cost functions. Corrected images and transformations were examined qualitatively and quantitatively using in-house developed code. Fractional anisotropy (FA) and mean diffusivity (MD) indices were calculated and tested for statistical significance pre- and post- motion correction. Images corrected using rigid methods showed improvements in image quality, while affine methods frequently showed residual distortions in corrected images. Blinded evaluation of pre and post correction images showed significant improvement in cord homogeneity and edge conspicuity in corrected images (p<0.0001). The average FA changes were statistically significant (p<0.0001) in the spinal cord injury group, while healthy subjects showed less FA change and were not significant. In both healthy subjects and subjects with spinal cord injury, quantitative and qualitative analysis showed the rigid scaled-least-squares registration technique to be the most reliable and effective in improving image quality.

KW - Adolescent

KW - Algorithms

KW - Artifacts

KW - Child

KW - Diffusion Tensor Imaging

KW - Female

KW - Humans

KW - Image Enhancement

KW - Image Interpretation, Computer-Assisted

KW - Male

KW - Motion

KW - Pattern Recognition, Automated

KW - Sensitivity and Specificity

KW - Spinal Cord

KW - Spinal Cord Injuries

KW - Subtraction Technique

KW - Young Adult

U2 - 10.1016/j.mri.2014.01.020

DO - 10.1016/j.mri.2014.01.020

M3 - SCORING: Journal article

C2 - 24629515

VL - 32

SP - 433

EP - 439

JO - MAGN RESON IMAGING

JF - MAGN RESON IMAGING

SN - 0730-725X

IS - 5

ER -