An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury
Standard
An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury. / Middleton, Devon M; Mohamed, Feroze B; Barakat, Nadia; Hunter, Louis N; Shellikeri, Sphoorti; Finsterbusch, Jürgen; Faro, Scott H; Shah, Pallav; Samdani, Amer F; Mulcahey, M J.
in: MAGN RESON IMAGING, Jahrgang 32, Nr. 5, 01.06.2014, S. 433-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - An investigation of motion correction algorithms for pediatric spinal cord DTI in healthy subjects and patients with spinal cord injury
AU - Middleton, Devon M
AU - Mohamed, Feroze B
AU - Barakat, Nadia
AU - Hunter, Louis N
AU - Shellikeri, Sphoorti
AU - Finsterbusch, Jürgen
AU - Faro, Scott H
AU - Shah, Pallav
AU - Samdani, Amer F
AU - Mulcahey, M J
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Patient and physiological motion can cause artifacts in DTI of the spinal cord which can impact image quality and diffusion indices. The purpose of this investigation was to determine a reliable motion correction method for pediatric spinal cord DTI and show effects of motion correction on DTI parameters in healthy subjects and patients with spinal cord injury. Ten healthy subjects and ten subjects with spinal cord injury were scanned using a 3T scanner. Images were acquired with an inner field-of-view DTI sequence covering cervical spine levels C1 to C7. Images were corrected for motion using two types of transformation (rigid and affine) and three cost functions. Corrected images and transformations were examined qualitatively and quantitatively using in-house developed code. Fractional anisotropy (FA) and mean diffusivity (MD) indices were calculated and tested for statistical significance pre- and post- motion correction. Images corrected using rigid methods showed improvements in image quality, while affine methods frequently showed residual distortions in corrected images. Blinded evaluation of pre and post correction images showed significant improvement in cord homogeneity and edge conspicuity in corrected images (p<0.0001). The average FA changes were statistically significant (p<0.0001) in the spinal cord injury group, while healthy subjects showed less FA change and were not significant. In both healthy subjects and subjects with spinal cord injury, quantitative and qualitative analysis showed the rigid scaled-least-squares registration technique to be the most reliable and effective in improving image quality.
AB - Patient and physiological motion can cause artifacts in DTI of the spinal cord which can impact image quality and diffusion indices. The purpose of this investigation was to determine a reliable motion correction method for pediatric spinal cord DTI and show effects of motion correction on DTI parameters in healthy subjects and patients with spinal cord injury. Ten healthy subjects and ten subjects with spinal cord injury were scanned using a 3T scanner. Images were acquired with an inner field-of-view DTI sequence covering cervical spine levels C1 to C7. Images were corrected for motion using two types of transformation (rigid and affine) and three cost functions. Corrected images and transformations were examined qualitatively and quantitatively using in-house developed code. Fractional anisotropy (FA) and mean diffusivity (MD) indices were calculated and tested for statistical significance pre- and post- motion correction. Images corrected using rigid methods showed improvements in image quality, while affine methods frequently showed residual distortions in corrected images. Blinded evaluation of pre and post correction images showed significant improvement in cord homogeneity and edge conspicuity in corrected images (p<0.0001). The average FA changes were statistically significant (p<0.0001) in the spinal cord injury group, while healthy subjects showed less FA change and were not significant. In both healthy subjects and subjects with spinal cord injury, quantitative and qualitative analysis showed the rigid scaled-least-squares registration technique to be the most reliable and effective in improving image quality.
KW - Adolescent
KW - Algorithms
KW - Artifacts
KW - Child
KW - Diffusion Tensor Imaging
KW - Female
KW - Humans
KW - Image Enhancement
KW - Image Interpretation, Computer-Assisted
KW - Male
KW - Motion
KW - Pattern Recognition, Automated
KW - Sensitivity and Specificity
KW - Spinal Cord
KW - Spinal Cord Injuries
KW - Subtraction Technique
KW - Young Adult
U2 - 10.1016/j.mri.2014.01.020
DO - 10.1016/j.mri.2014.01.020
M3 - SCORING: Journal article
C2 - 24629515
VL - 32
SP - 433
EP - 439
JO - MAGN RESON IMAGING
JF - MAGN RESON IMAGING
SN - 0730-725X
IS - 5
ER -