An inhibitory gate for state transition in cortex
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An inhibitory gate for state transition in cortex. / Zucca, Stefano; D'Urso, Giulia; Pasquale, Valentina; Vecchia, Dania; Pica, Giuseppe; Bovetti, Serena; Moretti, Claudio; Varani, Stefano; Molano-Mazón, Manuel; Chiappalone, Michela; Panzeri, Stefano; Fellin, Tommaso.
In: ELIFE, Vol. 6, 16.05.2017.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - An inhibitory gate for state transition in cortex
AU - Zucca, Stefano
AU - D'Urso, Giulia
AU - Pasquale, Valentina
AU - Vecchia, Dania
AU - Pica, Giuseppe
AU - Bovetti, Serena
AU - Moretti, Claudio
AU - Varani, Stefano
AU - Molano-Mazón, Manuel
AU - Chiappalone, Michela
AU - Panzeri, Stefano
AU - Fellin, Tommaso
PY - 2017/5/16
Y1 - 2017/5/16
N2 - Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.
AB - Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.
KW - Animals
KW - Cerebral Cortex/physiology
KW - Electroencephalography
KW - Interneurons/physiology
KW - Mice
KW - Neural Inhibition
KW - Optogenetics
KW - Sleep
KW - Wakefulness
U2 - 10.7554/eLife.26177
DO - 10.7554/eLife.26177
M3 - SCORING: Journal article
C2 - 28509666
VL - 6
JO - ELIFE
JF - ELIFE
SN - 2050-084X
ER -