PortalPublikationenAn inhibitory gate for state transition in cortex

An inhibitory gate for state transition in cortex

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An inhibitory gate for state transition in cortex. / Zucca, Stefano; D'Urso, Giulia; Pasquale, Valentina; Vecchia, Dania; Pica, Giuseppe; Bovetti, Serena; Moretti, Claudio; Varani, Stefano; Molano-Mazón, Manuel; Chiappalone, Michela; Panzeri, Stefano; Fellin, Tommaso.

in: ELIFE, Jahrgang 6, 16.05.2017.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zucca, S, D'Urso, G, Pasquale, V, Vecchia, D, Pica, G, Bovetti, S, Moretti, C, Varani, S, Molano-Mazón, M, Chiappalone, M, Panzeri, S & Fellin, T 2017, 'An inhibitory gate for state transition in cortex', ELIFE, Jg. 6. https://doi.org/10.7554/eLife.26177

APA

Zucca, S., D'Urso, G., Pasquale, V., Vecchia, D., Pica, G., Bovetti, S., Moretti, C., Varani, S., Molano-Mazón, M., Chiappalone, M., Panzeri, S., & Fellin, T. (2017). An inhibitory gate for state transition in cortex. ELIFE, 6. https://doi.org/10.7554/eLife.26177

Vancouver

Zucca S, D'Urso G, Pasquale V, Vecchia D, Pica G, Bovetti S et al. An inhibitory gate for state transition in cortex. ELIFE. 2017 Mai 16;6. https://doi.org/10.7554/eLife.26177

Bibtex

@article{25f3f9af77214d79a06eff154b4acf43,
title = "An inhibitory gate for state transition in cortex",
abstract = "Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.",
keywords = "Animals, Cerebral Cortex/physiology, Electroencephalography, Interneurons/physiology, Mice, Neural Inhibition, Optogenetics, Sleep, Wakefulness",
author = "Stefano Zucca and Giulia D'Urso and Valentina Pasquale and Dania Vecchia and Giuseppe Pica and Serena Bovetti and Claudio Moretti and Stefano Varani and Manuel Molano-Maz{\'o}n and Michela Chiappalone and Stefano Panzeri and Tommaso Fellin",
year = "2017",
month = may,
day = "16",
doi = "10.7554/eLife.26177",
language = "English",
volume = "6",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - An inhibitory gate for state transition in cortex

AU - Zucca, Stefano

AU - D'Urso, Giulia

AU - Pasquale, Valentina

AU - Vecchia, Dania

AU - Pica, Giuseppe

AU - Bovetti, Serena

AU - Moretti, Claudio

AU - Varani, Stefano

AU - Molano-Mazón, Manuel

AU - Chiappalone, Michela

AU - Panzeri, Stefano

AU - Fellin, Tommaso

PY - 2017/5/16

Y1 - 2017/5/16

N2 - Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.

AB - Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.

KW - Animals

KW - Cerebral Cortex/physiology

KW - Electroencephalography

KW - Interneurons/physiology

KW - Mice

KW - Neural Inhibition

KW - Optogenetics

KW - Sleep

KW - Wakefulness

U2 - 10.7554/eLife.26177

DO - 10.7554/eLife.26177

M3 - SCORING: Journal article

C2 - 28509666

VL - 6

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -