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AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.

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AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation. / Holbro, Niklaus; Grunditz, Asa; Wiegert, J. Simon; Oertner, Thomas G.

In: P NATL ACAD SCI USA, Vol. 107, No. 36, 36, 2010, p. 15975-15980.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Holbro, N, Grunditz, A, Wiegert, JS & Oertner, TG 2010, 'AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.', P NATL ACAD SCI USA, vol. 107, no. 36, 36, pp. 15975-15980. <http://www.ncbi.nlm.nih.gov/pubmed/20798031?dopt=Citation>

APA

Holbro, N., Grunditz, A., Wiegert, J. S., & Oertner, T. G. (2010). AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation. P NATL ACAD SCI USA, 107(36), 15975-15980. [36]. http://www.ncbi.nlm.nih.gov/pubmed/20798031?dopt=Citation

Vancouver

Holbro N, Grunditz A, Wiegert JS, Oertner TG. AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation. P NATL ACAD SCI USA. 2010;107(36):15975-15980. 36.

Bibtex

@article{edd66fec8ac144f2beb1710d6e8e98cb,
title = "AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.",
abstract = "Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.",
keywords = "Animals, Rats, Rats, Wistar, Long-Term Potentiation, *Action Potentials, Calcium/*metabolism, Hippocampus/physiology, Receptors, AMPA/*physiology, Animals, Rats, Rats, Wistar, Long-Term Potentiation, *Action Potentials, Calcium/*metabolism, Hippocampus/physiology, Receptors, AMPA/*physiology",
author = "Niklaus Holbro and Asa Grunditz and Wiegert, {J. Simon} and Oertner, {Thomas G.}",
year = "2010",
language = "English",
volume = "107",
pages = "15975--15980",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "36",

}

RIS

TY - JOUR

T1 - AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.

AU - Holbro, Niklaus

AU - Grunditz, Asa

AU - Wiegert, J. Simon

AU - Oertner, Thomas G.

PY - 2010

Y1 - 2010

N2 - Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.

AB - Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.

KW - Animals

KW - Rats

KW - Rats, Wistar

KW - Long-Term Potentiation

KW - Action Potentials

KW - Calcium/metabolism

KW - Hippocampus/physiology

KW - Receptors, AMPA/physiology

KW - Animals

KW - Rats

KW - Rats, Wistar

KW - Long-Term Potentiation

KW - Action Potentials

KW - Calcium/metabolism

KW - Hippocampus/physiology

KW - Receptors, AMPA/physiology

M3 - SCORING: Journal article

VL - 107

SP - 15975

EP - 15980

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 36

M1 - 36

ER -