AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.
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AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation. / Holbro, Niklaus; Grunditz, Asa; Wiegert, J. Simon; Oertner, Thomas G.
in: P NATL ACAD SCI USA, Jahrgang 107, Nr. 36, 36, 2010, S. 15975-15980.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.
AU - Holbro, Niklaus
AU - Grunditz, Asa
AU - Wiegert, J. Simon
AU - Oertner, Thomas G.
PY - 2010
Y1 - 2010
N2 - Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.
AB - Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.
KW - Animals
KW - Rats
KW - Rats, Wistar
KW - Long-Term Potentiation
KW - Action Potentials
KW - Calcium/metabolism
KW - Hippocampus/physiology
KW - Receptors, AMPA/physiology
KW - Animals
KW - Rats
KW - Rats, Wistar
KW - Long-Term Potentiation
KW - Action Potentials
KW - Calcium/metabolism
KW - Hippocampus/physiology
KW - Receptors, AMPA/physiology
M3 - SCORING: Journal article
VL - 107
SP - 15975
EP - 15980
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 36
M1 - 36
ER -