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β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

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β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. / Kitase, Yukiko; Vallejo, Julian A.; Gutheil, William ; Vemula, Harika ; Jähn, Katharina; Yi, Jianxun ; Zhou, Jingsong ; Brotto, Marco ; Bonewald, Lynda F.

In: CELL REP, Vol. 22, No. 6, 06.02.2018, p. 1531-1544.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kitase, Y, Vallejo, JA, Gutheil, W, Vemula, H, Jähn, K, Yi, J, Zhou, J, Brotto, M & Bonewald, LF 2018, 'β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor', CELL REP, vol. 22, no. 6, pp. 1531-1544. https://doi.org/10.1016/j.celrep.2018.01.041

APA

Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F. (2018). β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. CELL REP, 22(6), 1531-1544. https://doi.org/10.1016/j.celrep.2018.01.041

Vancouver

Kitase Y, Vallejo JA, Gutheil W, Vemula H, Jähn K, Yi J et al. β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. CELL REP. 2018 Feb 6;22(6):1531-1544. https://doi.org/10.1016/j.celrep.2018.01.041

Bibtex

@article{ee75bd8e67a4483bb946afc832d785ac,
title = "β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor",
abstract = "Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.",
author = "Yukiko Kitase and Vallejo, {Julian A.} and William Gutheil and Harika Vemula and Katharina J{\"a}hn and Jianxun Yi and Jingsong Zhou and Marco Brotto and Bonewald, {Lynda F.}",
note = "Copyright {\textcopyright} 2018 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = feb,
day = "6",
doi = "10.1016/j.celrep.2018.01.041",
language = "English",
volume = "22",
pages = "1531--1544",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

AU - Kitase, Yukiko

AU - Vallejo, Julian A.

AU - Gutheil, William

AU - Vemula, Harika

AU - Jähn, Katharina

AU - Yi, Jianxun

AU - Zhou, Jingsong

AU - Brotto, Marco

AU - Bonewald, Lynda F.

N1 - Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2018/2/6

Y1 - 2018/2/6

N2 - Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.

AB - Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.

U2 - 10.1016/j.celrep.2018.01.041

DO - 10.1016/j.celrep.2018.01.041

M3 - SCORING: Journal article

C2 - 29425508

VL - 22

SP - 1531

EP - 1544

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 6

ER -