β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor
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β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. / Kitase, Yukiko; Vallejo, Julian A.; Gutheil, William ; Vemula, Harika ; Jähn, Katharina; Yi, Jianxun ; Zhou, Jingsong ; Brotto, Marco ; Bonewald, Lynda F.
in: CELL REP, Jahrgang 22, Nr. 6, 06.02.2018, S. 1531-1544.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor
AU - Kitase, Yukiko
AU - Vallejo, Julian A.
AU - Gutheil, William
AU - Vemula, Harika
AU - Jähn, Katharina
AU - Yi, Jianxun
AU - Zhou, Jingsong
AU - Brotto, Marco
AU - Bonewald, Lynda F.
N1 - Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2018/2/6
Y1 - 2018/2/6
N2 - Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.
AB - Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.
U2 - 10.1016/j.celrep.2018.01.041
DO - 10.1016/j.celrep.2018.01.041
M3 - SCORING: Journal article
C2 - 29425508
VL - 22
SP - 1531
EP - 1544
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 6
ER -