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Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage

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Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage. / Rejdak, Robert; Zarnowski, Tomasz; Turski, Waldemar A; Kocki, Tomasz; Zagorski, Zbigniew; Zrenner, Eberhart; Schuettauf, Frank.

In: VISION RES, Vol. 43, No. 5, 03.2003, p. 497-503.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rejdak, R, Zarnowski, T, Turski, WA, Kocki, T, Zagorski, Z, Zrenner, E & Schuettauf, F 2003, 'Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage', VISION RES, vol. 43, no. 5, pp. 497-503. https://doi.org/10.1016/s0042-6989(02)00682-x

APA

Rejdak, R., Zarnowski, T., Turski, W. A., Kocki, T., Zagorski, Z., Zrenner, E., & Schuettauf, F. (2003). Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage. VISION RES, 43(5), 497-503. https://doi.org/10.1016/s0042-6989(02)00682-x

Vancouver

Rejdak R, Zarnowski T, Turski WA, Kocki T, Zagorski Z, Zrenner E et al. Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage. VISION RES. 2003 Mar;43(5):497-503. https://doi.org/10.1016/s0042-6989(02)00682-x

Bibtex

@article{e9c75af2b6da40aa83f5f567caf04782,
title = "Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage",
abstract = "The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases.",
keywords = "Animals, Cell Death/drug effects, Chromatography, High Pressure Liquid, Kynurenic Acid/metabolism, Male, N-Methylaspartate/pharmacology, Rats, Rats, Inbred BN, Retina/metabolism, Retinal Degeneration/chemically induced, Retinal Ganglion Cells/drug effects",
author = "Robert Rejdak and Tomasz Zarnowski and Turski, {Waldemar A} and Tomasz Kocki and Zbigniew Zagorski and Eberhart Zrenner and Frank Schuettauf",
year = "2003",
month = mar,
doi = "10.1016/s0042-6989(02)00682-x",
language = "English",
volume = "43",
pages = "497--503",
journal = "VISION RES",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "5",

}

RIS

TY - JOUR

T1 - Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage

AU - Rejdak, Robert

AU - Zarnowski, Tomasz

AU - Turski, Waldemar A

AU - Kocki, Tomasz

AU - Zagorski, Zbigniew

AU - Zrenner, Eberhart

AU - Schuettauf, Frank

PY - 2003/3

Y1 - 2003/3

N2 - The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases.

AB - The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases.

KW - Animals

KW - Cell Death/drug effects

KW - Chromatography, High Pressure Liquid

KW - Kynurenic Acid/metabolism

KW - Male

KW - N-Methylaspartate/pharmacology

KW - Rats

KW - Rats, Inbred BN

KW - Retina/metabolism

KW - Retinal Degeneration/chemically induced

KW - Retinal Ganglion Cells/drug effects

U2 - 10.1016/s0042-6989(02)00682-x

DO - 10.1016/s0042-6989(02)00682-x

M3 - SCORING: Journal article

C2 - 12594996

VL - 43

SP - 497

EP - 503

JO - VISION RES

JF - VISION RES

SN - 0042-6989

IS - 5

ER -