Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage
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Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage. / Rejdak, Robert; Zarnowski, Tomasz; Turski, Waldemar A; Kocki, Tomasz; Zagorski, Zbigniew; Zrenner, Eberhart; Schuettauf, Frank.
in: VISION RES, Jahrgang 43, Nr. 5, 03.2003, S. 497-503.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage
AU - Rejdak, Robert
AU - Zarnowski, Tomasz
AU - Turski, Waldemar A
AU - Kocki, Tomasz
AU - Zagorski, Zbigniew
AU - Zrenner, Eberhart
AU - Schuettauf, Frank
PY - 2003/3
Y1 - 2003/3
N2 - The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases.
AB - The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases.
KW - Animals
KW - Cell Death/drug effects
KW - Chromatography, High Pressure Liquid
KW - Kynurenic Acid/metabolism
KW - Male
KW - N-Methylaspartate/pharmacology
KW - Rats
KW - Rats, Inbred BN
KW - Retina/metabolism
KW - Retinal Degeneration/chemically induced
KW - Retinal Ganglion Cells/drug effects
U2 - 10.1016/s0042-6989(02)00682-x
DO - 10.1016/s0042-6989(02)00682-x
M3 - SCORING: Journal article
C2 - 12594996
VL - 43
SP - 497
EP - 503
JO - VISION RES
JF - VISION RES
SN - 0042-6989
IS - 5
ER -