Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.
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Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up. / Krappmann, Paul; Paulides, Marios; Stöhr, Wolfgang; Ittner, Edith; Plattig, Bernhard; Nickel, Petra; Lackner, Herwig; Schrappe, Martin; Janka-Schaub, Gritta; Beck, Jörn D; Langer, Thorsten.
In: PEDIATR HEMAT ONCOL, Vol. 24, No. 2, 2, 2007, p. 101-109.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.
AU - Krappmann, Paul
AU - Paulides, Marios
AU - Stöhr, Wolfgang
AU - Ittner, Edith
AU - Plattig, Bernhard
AU - Nickel, Petra
AU - Lackner, Herwig
AU - Schrappe, Martin
AU - Janka-Schaub, Gritta
AU - Beck, Jörn D
AU - Langer, Thorsten
PY - 2007
Y1 - 2007
N2 - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 +/- 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.
AB - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 +/- 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.
M3 - SCORING: Zeitschriftenaufsatz
VL - 24
SP - 101
EP - 109
JO - PEDIATR HEMAT ONCOL
JF - PEDIATR HEMAT ONCOL
SN - 0888-0018
IS - 2
M1 - 2
ER -