Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.

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Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up. / Krappmann, Paul; Paulides, Marios; Stöhr, Wolfgang; Ittner, Edith; Plattig, Bernhard; Nickel, Petra; Lackner, Herwig; Schrappe, Martin; Janka-Schaub, Gritta; Beck, Jörn D; Langer, Thorsten.

in: PEDIATR HEMAT ONCOL, Jahrgang 24, Nr. 2, 2, 2007, S. 101-109.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{bd8b8d10bc2c49ff9edd87b8730bd3da,
title = "Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.",
abstract = "In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 +/- 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.",
author = "Paul Krappmann and Marios Paulides and Wolfgang St{\"o}hr and Edith Ittner and Bernhard Plattig and Petra Nickel and Herwig Lackner and Martin Schrappe and Gritta Janka-Schaub and Beck, {J{\"o}rn D} and Thorsten Langer",
year = "2007",
language = "Deutsch",
volume = "24",
pages = "101--109",
journal = "PEDIATR HEMAT ONCOL",
issn = "0888-0018",
publisher = "informa healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.

AU - Krappmann, Paul

AU - Paulides, Marios

AU - Stöhr, Wolfgang

AU - Ittner, Edith

AU - Plattig, Bernhard

AU - Nickel, Petra

AU - Lackner, Herwig

AU - Schrappe, Martin

AU - Janka-Schaub, Gritta

AU - Beck, Jörn D

AU - Langer, Thorsten

PY - 2007

Y1 - 2007

N2 - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 +/- 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.

AB - In a multicenter study the authors prospectively investigated neurocognitive function in childhood ALL patients. Sixty-six patients (mean age at diagnosis 7.9 +/- 3.6 years, 34 female), treated with repeated intrathecal and systemical methotrexate administrations without cranial irradiation, underwent psychometric testing for intelligence, concentration, and visual-motor integration postdiagnosis and after reinduction therapy. Although there was a statistically significant decline of intellectual function after reinduction therapy for younger patients and girls (IQ scores still within normative data range), there were no differences in visual-motor performance and concentration over the time of induction therapy. Thus, neurocognitive examination should focus on younger ALL patients and girls.

M3 - SCORING: Zeitschriftenaufsatz

VL - 24

SP - 101

EP - 109

JO - PEDIATR HEMAT ONCOL

JF - PEDIATR HEMAT ONCOL

SN - 0888-0018

IS - 2

M1 - 2

ER -